Ultra-uniform nanocrystalline hydroxyapatite ceramics via two-step sintering and quenching

IF 3.8 3区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Journal of the American Ceramic Society Pub Date : 2025-08-07 DOI:10.1111/jace.70155

Tinghan He, Ruitao Hu, Hao Shi, Qipeng Li, Yuyi Wang, Cong Feng, Yumei Xiao, Ye Wang, Xiangfeng Li, Xiangdong Zhu, Xingdong Zhang

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Abstract

The enhancement of the mechanical properties of hydroxyapatite (HA) bioceramics constitutes a significant research focus in the biomedical field. The present study is dedicated to the preparation of ultra-uniform nanocrystalline HA bioceramics and their influence on the mechanical properties and biological performances. First, HA powder with a uniform dispersion was fabricated through a sequential process encompassing low-temperature pre-sintering, ball milling, and gradient centrifugation. Subsequently, the green body underwent the two-step sintering and the quenching process to enhance the density and mechanical strength. The nanoceramics displayed excellent hydrophilicity and increased roughness. The nanoindentation tests revealed that the nanoceramics did not undergo any elastic-plastic deformation, and there was no indentation size effect phenomenon. In vitro biological performances suggested that the nanoceramics have the potential to facilitate osteogenic differentiation of bone marrow mesenchymal stem cells. Therefore, it can be concluded that the construction of ultra-uniform nanocrystalline is an effective approach to improve the mechanical and biological properties of HA bioceramics.

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两步烧结淬火制备超均匀羟基磷灰石纳米晶陶瓷

羟基磷灰石（HA）生物陶瓷力学性能的增强是生物医学领域的一个重要研究热点。本研究致力于超均匀纳米晶HA生物陶瓷的制备及其对力学性能和生物性能的影响。首先，通过低温预烧结、球磨和梯度离心等顺序工艺制备分散性均匀的HA粉末。然后对坯体进行两步烧结和淬火处理，以提高密度和机械强度。纳米陶瓷表现出优异的亲水性和粗糙度。纳米压痕试验表明，纳米陶瓷不发生弹塑性变形，不存在压痕尺寸效应现象。体外生物学性能表明纳米陶瓷具有促进骨髓间充质干细胞成骨分化的潜力。由此可见，构建超均匀纳米晶是提高HA生物陶瓷力学性能和生物学性能的有效途径。

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来源期刊

Journal of the American Ceramic Society 工程技术-材料科学：硅酸盐

CiteScore

7.50

自引率

7.70%

发文量

590

审稿时长

2.1 months

期刊介绍： The Journal of the American Ceramic Society contains records of original research that provide insight into or describe the science of ceramic and glass materials and composites based on ceramics and glasses. These papers include reports on discovery, characterization, and analysis of new inorganic, non-metallic materials; synthesis methods; phase relationships; processing approaches; microstructure-property relationships; and functionalities. Of great interest are works that support understanding founded on fundamental principles using experimental, theoretical, or computational methods or combinations of those approaches. All the published papers must be of enduring value and relevant to the science of ceramics and glasses or composites based on those materials. Papers on fundamental ceramic and glass science are welcome including those in the following areas: Enabling materials for grand challenges[...] Materials design, selection, synthesis and processing methods[...] Characterization of compositions, structures, defects, and properties along with new methods [...] Mechanisms, Theory, Modeling, and Simulation[...] JACerS accepts submissions of full-length Articles reporting original research, in-depth Feature Articles, Reviews of the state-of-the-art with compelling analysis, and Rapid Communications which are short papers with sufficient novelty or impact to justify swift publication.