Cr3+-Doped γ- and β-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent Luminescence, and Biocompatibility

IF 7.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Encarnación Arroyo, José M. Monje-Moreno, Beatriz Torres-Herrero, Manuel J. Munoz, Jesús M. de la Fuente, Ana I. Becerro, Manuel Ocaña
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引用次数: 0

Abstract

Persistent luminescent (PersL) nanophosphors that emit in the near infrared (NIR) region are promising nanoprobes for in vivo bioimaging. Although Cr3+-doped zinc gallate nanoparticles (NPs) have been widely studied as in vivo bioimaging nanoprobes due to their NIR PersL emission at 695 nm, the simpler Cr3+-doped gallium oxide system has been less explored despite its deeper NIR emission (760 nm), which favors tissue penetration. This is likely due the lack of synthesis methods that render Ga2O3-based NPs suitable for in vivo applications. In this paper, a novel method for the synthesis of uniform and hydrophilic γ-Ga2O3:Cr3+ NPs is reported, whose photoluminescence (PL) and PersL are optimized by adjusting their Cr3+ content. Such properties are further greatly improved through an annealing process at high temperature, which result in the transformation of its crystal structure into the β-phase. The obtained β-Ga2O3:Cr3+ NPs are colloidally stable in a physiological pH simulator medium and are nontoxic for cells. Finally, this work studies, for the first time in literature, the in vivo biocompatibility of such NPs using a Caenorhabditis elegans (C. elegans) animal model, finding that their morbidity and reproductive toxicity are negligible. In summary, the reported NPs are excellent candidates for their use as a NIR PersL probes for in vivo bioimaging.

Abstract Image

用于生物成像的Cr3+掺杂γ-和β-氧化镓纳米探针:合成、持续发光和生物相容性
在近红外(NIR)区域发射的持续发光(PersL)纳米荧光粉是很有前途的体内生物成像纳米探针。虽然Cr3+掺杂的没吃子酸锌纳米粒子(NPs)由于其695 nm的近红外perl发射而被广泛研究为体内生物成像纳米探针,但更简单的Cr3+掺杂氧化镓体系尽管具有更深的近红外发射(760 nm),有利于组织穿透,但研究较少。这可能是由于缺乏适合体内应用的ga2o3基NPs的合成方法。本文报道了一种合成均匀亲水性γ-Ga2O3:Cr3+ NPs的新方法,通过调节其Cr3+含量来优化其光致发光(PL)和PersL。通过高温退火工艺进一步提高了这些性能,使其晶体结构转变为β相。所得β-Ga2O3:Cr3+ NPs在生理pH模拟培养基中胶体稳定,对细胞无毒。最后,本文首次利用秀丽隐杆线虫(C. elegans)动物模型研究了这些NPs的体内生物相容性,发现它们的发病率和生殖毒性可以忽略不计。总之,所报道的NPs是用于体内生物成像的近红外PersL探针的优秀候选者。
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来源期刊
Advanced Optical Materials
Advanced Optical Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-OPTICS
CiteScore
13.70
自引率
6.70%
发文量
883
审稿时长
1.5 months
期刊介绍: Advanced Optical Materials, part of the esteemed Advanced portfolio, is a unique materials science journal concentrating on all facets of light-matter interactions. For over a decade, it has been the preferred optical materials journal for significant discoveries in photonics, plasmonics, metamaterials, and more. The Advanced portfolio from Wiley is a collection of globally respected, high-impact journals that disseminate the best science from established and emerging researchers, aiding them in fulfilling their mission and amplifying the reach of their scientific discoveries.
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