Design and Development of a Button-Style Transcutaneous Vagus Nerve Stimulation Device with Integrated PPG for HRV Monitoring†

IF 1.1 4区工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEJ Transactions on Electrical and Electronic Engineering Pub Date : 2025-08-02 DOI:10.1002/tee.70119

Thien-Luan Phan, Peng-Ta Liu, Nguyen Van Hieu, Ha Anh T. Nguyen, Ngoc Luan Tran, Duc Huy Nguyen, Ting-Yi Shen, Quy Ha Luu, Daniel H. K. Chow, Henry J. H. Chen, Chih-Lung Lin, Pei-Yi Chu, Pai-Yi Chiu, Cheng-Chung Chang, Congo Tak Shing Ching, Trung Nghia Tran

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Abstract

Transcutaneous vagus nerve stimulation (tVNS) through auricular points emerges as a potential solution for mitigating depressive symptoms. This paper presents the development and evaluation of a button-style transcutaneous auricular vagus nerve stimulation (taVNS) device for portable treatment and research applications. The device integrates photoplethysmography (PPG) for heart rate variability (HRV) monitoring, enabling real-time evaluation of autonomic nervous system functionality. The system incorporates a user-friendly design, including an Android application for monitoring HRV metrics and adjusting stimulation parameters, ensuring accessibility and personalization. In an initial evaluation involving nine volunteers, five participants demonstrated significant improvements in autonomic nervous system functionality, as evidenced by enhanced SDNN values, while four participants showed minimal response. These results confirmed the usability of the closed-loop device and could potentially enhance future research efforts in personalized taVNS therapy. © 2025 Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.

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用于HRV监测的带有集成PPG的按钮式经皮迷走神经刺激装置的设计与开发

通过耳穴经皮迷走神经刺激（tVNS）是缓解抑郁症状的潜在解决方案。本文介绍了一种钮扣式经皮耳迷走神经刺激装置（taVNS）的研制和评价，用于便携式治疗和研究应用。该设备集成了用于心率变异性（HRV）监测的光电容积脉搏图（PPG），能够实时评估自主神经系统功能。该系统采用了用户友好的设计，包括一个用于监测HRV指标和调整增产参数的Android应用程序，确保可访问性和个性化。在涉及9名志愿者的初步评估中，5名参与者表现出自主神经系统功能的显着改善，正如SDNN值增强所证明的那样，而4名参与者表现出最小的反应。这些结果证实了闭环装置的可用性，并可能潜在地加强个性化taVNS治疗的未来研究工作。©2025日本电气工程师协会和Wiley期刊有限责任公司。

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来源期刊

IEEJ Transactions on Electrical and Electronic Engineering 工程技术-工程：电子与电气

CiteScore

2.70

自引率

10.00%

发文量

199

审稿时长

4.3 months

期刊介绍： IEEJ Transactions on Electrical and Electronic Engineering (hereinafter called TEEE ) publishes 6 times per year as an official journal of the Institute of Electrical Engineers of Japan (hereinafter "IEEJ"). This peer-reviewed journal contains original research papers and review articles on the most important and latest technological advances in core areas of Electrical and Electronic Engineering and in related disciplines. The journal also publishes short communications reporting on the results of the latest research activities TEEE ) aims to provide a new forum for IEEJ members in Japan as well as fellow researchers in Electrical and Electronic Engineering from around the world to exchange ideas and research findings.