Percutaneous Orthotopic Transcatheter Tricuspid Valve Replacement for Native Valve Destruction After Endocarditis

Q4 Medicine

JACC. Case reports Pub Date : 2025-10-01 DOI:10.1016/j.jaccas.2025.105280

Andrea Ruberti MD , Laura Sanchis MD, PhD , Andrea Arenas-Loriente MD , Blanca Domenech-Ximenos MD, PhD , Eduardo Flores-Umanzor MD, PhD , Ander Regueiro MD, PhD , Marta Farrero MD, PhD , Marta Sitges MD, PhD , Xavier Freixa MD, PhD , Omar Abdul-Jawad Altisent MD, PhD

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Abstract

Background

Transcatheter tricuspid valve replacement (TTVR) is emerging as an option for treating severe tricuspid regurgitation (TR) in patients at high surgical risk.

Case Summary

A 59-year-old man with torrential TR and right heart failure following Staphylococcus aureus tricuspid valve infective endocarditis and extensive leaflet destruction was successfully treated with orthotopic TTVR using the LuX-Valve Plus system (Jenscare), resulting in significant clinical improvement and favorable right ventricular remodeling.

Discussion

The LuX-Valve Plus, delivered via transjugular access, enables optimal coaxial alignment during deployment. Its unique features—leaflet graspers, a septal anchoring mechanism, and a flexible frame—provide stability and preserve right ventricular function, making it suitable for complex tricuspid anatomies.

Take-Home Messages

Orthotopic TTVR with the LuX-Valve Plus offers a viable option for patients with severe TR and extensive leaflet destruction, previously considered ineligible for surgical or transcatheter repair. Multimodality imaging is essential for procedural planning and optimal outcomes.

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心内膜炎后原位瓣膜破坏的经皮原位经导管三尖瓣置换术

背景：经导管三尖瓣置换术（TTVR）正在成为治疗高手术风险患者严重三尖瓣返流（TR）的一种选择。一例59岁男性患者，因金黄色葡萄球菌性三尖瓣感染性心内膜炎和广泛的小叶破坏而发生重度TR和右心衰，我们使用LuX-Valve Plus系统（Jenscare）成功地进行了原位TTVR治疗，取得了显著的临床改善和良好的右心室重构。LuX-Valve Plus通过经颈静脉输送，可在部署过程中实现最佳同轴对准。其独特的功能-小叶抓握器，室间隔锚定机制，和一个灵活的框架-提供稳定性和保留右心室功能，使其适用于复杂的三尖瓣解剖。LuX-Valve Plus的原位TTVR为严重TR和广泛小叶破坏的患者提供了可行的选择，这些患者以前被认为不适合手术或经导管修复。多模态成像对于手术计划和最佳结果至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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