Lactylation in Cardiovascular Diseases: Current Progress and Perspectives.

IF 5.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Journal of the American Heart Association Pub Date : 2025-10-07 Epub Date: 2025-09-30 DOI:10.1161/JAHA.125.043801
Zhi-Mo Wang, Qing-Wen Yu, Cong Wang, Shu-Hui Wang, Pei Wang, Li-Rong Zhang, Sheng-Na Han
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引用次数: 0

Abstract

Emerging evidence suggests that epigenetic modifications, including lactylation-a recently identified posttranslational modification-may play a role in cardiovascular diseases (CVDs). Lactylation occurs in both histone and nonhistone proteins and has been implicated in processes, such as inflammation, lipid metabolism, and angiogenesis, which are relevant to CVD pathogenesis. However, the mechanistic links between lactylation and CVDs remain poorly understood, with most supporting evidence derived from preclinical studies. This review summarizes the current knowledge on lactylation, including its regulatory enzymes and potential functional roles in CVDs. While preliminary, these insights may inform future research directions for therapeutic strategies, early diagnostics, and disease prevention. Further validation in clinical studies is needed to establish the significance of lactylation in CVDs.

心血管疾病中的乳酸酰化:目前的进展和前景。
新出现的证据表明,表观遗传修饰,包括最近发现的翻译后修饰乳酸化,可能在心血管疾病(cvd)中发挥作用。乳酸化发生在组蛋白和非组蛋白中,并与炎症、脂质代谢和血管生成等过程有关,这些过程与心血管疾病的发病有关。然而,乳酸化与心血管疾病之间的机制联系仍然知之甚少,大多数支持性证据来自临床前研究。本文综述了目前关于乳酸化的研究进展,包括其调节酶及其在心血管疾病中的潜在功能作用。虽然是初步的,但这些见解可能为未来的治疗策略、早期诊断和疾病预防的研究方向提供信息。需要进一步的临床研究验证来确定乳酸化在心血管疾病中的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of the American Heart Association
Journal of the American Heart Association CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
9.40
自引率
1.90%
发文量
1749
审稿时长
12 weeks
期刊介绍: As an Open Access journal, JAHA - Journal of the American Heart Association is rapidly and freely available, accelerating the translation of strong science into effective practice. JAHA is an authoritative, peer-reviewed Open Access journal focusing on cardiovascular and cerebrovascular disease. JAHA provides a global forum for basic and clinical research and timely reviews on cardiovascular disease and stroke. As an Open Access journal, its content is free on publication to read, download, and share, accelerating the translation of strong science into effective practice.
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