The Burden of Alopecia Areata and Management with Baricitinib in the United Arab Emirates: A Narrative Review.

Abstract

Alopecia areata is an inflammatory autoimmune disease that presents as non-scarring hair loss in adults and children and causes substantial psychological distress, economic burden, and reduced quality of life for those affected. Although steroids and immunosuppressants are common treatments for alopecia areata, results from studies of Janus kinase inhibitors in the systemic management of alopecia areata, including those from long-term efficacy and safety studies on the Janus kinase 1/2 inhibitor baricitinib, show promising results. Despite alopecia areata placing a burden on healthcare systems in the Middle East, published data on the overall prevalence, patient characteristics, and treatment landscape for alopecia areata across the region are sparse, and a lack of approved therapies and insufficient access to treatment are treatment obstacles. Herein, we describe the burden of alopecia areata on patients and healthcare systems, review publications from the United Arab Emirates (UAE) on alopecia areata, highlight gaps in the data, and review clinical trial publications on the management of alopecia areata with baricitinib, the first Janus kinase inhibitor approved for the treatment of alopecia areata in the UAE. A regional expert assessment of the burden of alopecia areata and unmet medical needs in the UAE is provided, along with an expert opinion on treating patients with severe alopecia areata.