Chlorobactine A, a Dimeric Dichlorated Metabolite from Marine-Derived Streptomyces thermolineatus NAK03196.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-30 DOI:10.1021/acs.orglett.5c03588

Guodong Zhang,Jing Shi,Chao Zhang,Wen Wang,Xiao Yang,Zijun Xiong,Shuai Ma,Rong Wang,Zhikai Guo,Ruihua Jiao

引用次数: 0

Abstract

Using the one strain many compounds (OSMAC) strategy and guided by LC-MS results, we explored the metabolites of marine algae-derived strain Streptomyces thermolineatus NAK03196 and discovered a new class of molecules with an unexpected skeleton, chlorobactine A (1). Its structure was determined by 1D and 2D NMR spectroscopy, HR-ESI-MS, single-crystal X-ray diffraction analysis (Cu Kα), and ECD calculation. Chlorobactine A (1) contains dichlorine atoms and possesses a unique [6/6/6] tricyclic fused skeleton structure. Meanwhile, a plausible biosynthetic pathway for 1 was proposed based on the molecular structures and bioinformatic analysis.

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海洋源热链霉菌NAK03196的二聚二氯代谢物氯巴碱A。

采用一株多化合物（OSMAC）策略，在LC-MS结果的指导下，我们对海洋藻类衍生菌株Streptomyces thermolineatus NAK03196的代谢产物进行了研究，发现了一类具有意想到的骨架的新分子——氯巴碱a(1)。通过1D和2D NMR、HR-ESI-MS、单晶x射线衍射分析（Cu Kα）和ECD计算确定了其结构。氯巴汀A(1)含有二氯原子，具有独特的[6/6/6]三环融合骨架结构。同时，基于分子结构和生物信息学分析，提出了1的生物合成途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.