Comparative evaluation of soft tissue wound healing in lateral eyebrow incisions with 5% w/v Panchavalkala water extract, 5% w/v Panchavalkala alcohol extract, 5% w/v Panchavalkalahydroalcohol extract - An interventional randomized study.

Abstract

Context: Panchavalkala extract has anti-inflammatory properties and has been tested in gynecological wounds, especially in cesearian wounds. The study aims at the extract being used for maxillofacial wounds, especially in lateral eyebrow incisions, which is the approach for the reduction of frontozygomatic fractures.

Aim: The study aims at evaluating the soft tissue wound healing in lateral eyebrow incisions with 5% w/v Panchavalkala water extract, 5% w/v Panchavalkala alcohol extract, and 5% w/v Panchavalkalahydroalcohol extract.

Settings and design: The randomized interventional study according to consort guidelines and ethical clearance, parallel-group design, and allocation groups (1:1:1) with four groups. Group 1: 11 patients having frontozygomatic fractures was applied with 5% w/v Panchavalkala water extract. Group 2: 11 patients with frontozygomatic fractures were applied with 5% w/v Panchavalkala alcohol extract. Group 3: 11 patients with frontozygomatic fractures were applied with 5% w/v Panchavalkala hydroalcohol extract. Group 4: 11 patients with frontozygomatic fractures were applied with Neosporin ointment (control).

Materials and methods: The Panchavalkala quath and its various group preparations were used, and preparation was applied in the lateral eyebrow incisions of isolated frontozygomatic fractures and evaluated. Evaluation involved measuring various parameters such as slough, swelling, redness, pain, discharge, tenderness, and malodor at specific intervals postoperatively (day 1, day 7, day 15, and day 30).

Statistical design: The groups were evaluated with Kruskal-Wallis analysis of variance (ANOVA) tests. Group 3, which received the 5% w/v panchavalkahydroalcohol extract, exhibited the highest level of improvement, followed by group 2 (5% w/v panchavalka alcohol extract), group 1 (5% w/v panchavalka water extract), and finally group 4 (Neosporin ointment).

Results: These findings strongly support the superior healing properties of the 5% w/v panchavalkahydroalcohol extract for soft tissue wound healing.

Conclusion: The 5% v/w hydroxyalcohol extract of Panchavalkala gave excellent results in terms of all parameters of healing compared to the other two groups and hence can be the future for many studies.