Shaping the future of urogynecology through regenerative medicine.

IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Tatyanna Henderson, Karen L Christman, Marianna Alperin
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引用次数: 0

Abstract

Purpose of review: The etiology of urogynecologic conditions is multifactorial and complex. However, the inability of the host pelvic tissues to repair and regain their original function in response to various insults, including maternal birth injury or age-related changes in the endogenous regenerative potential, underlies the pathophysiology of the morbid pelvic floor disorders (PFDs). Regenerative medicine approaches are poised to not only treat but potentially prevent the development of these deleterious conditions, the prevalence of which continues to increase. We aim to highlight the existent work at the crossroads of urogynecology and regenerative medicine and to underscore areas in need for continued and novel investigations.

Recent findings: Regenerative medicine techniques, including stem cell therapies, extracellular vesicles, secretomes, platelet-rich plasma, laser-based interventions, and bioinductive acellular scaffolds, are being studied in the context of urogynecology, with many showing promise in revolutionizing prevention and treatment of PFDs by enhancing constructive tissue repair.

Summary: Regenerative medicine techniques hold the key to changing the clinical paradigm in Urogynecology from reactive to preventive.

通过再生医学塑造泌尿妇科的未来。
综述的目的:泌尿妇科疾病的病因是多因素和复杂的。然而,宿主盆腔组织无法修复和恢复其原始功能以应对各种损伤,包括产妇分娩损伤或内源性再生潜能的年龄相关变化,这是病理性盆底疾病(PFDs)的病理生理学基础。再生医学方法不仅准备治疗,而且潜在地预防这些有害条件的发展,其患病率继续增加。我们的目标是强调在泌尿妇科和再生医学交叉领域的现有工作,并强调需要持续和新颖研究的领域。最新发现:再生医学技术,包括干细胞疗法、细胞外囊泡、分泌组、富血小板血浆、激光干预和生物诱导脱细胞支架,正在泌尿妇科的背景下进行研究,其中许多技术显示出通过增强建设性组织修复来彻底预防和治疗PFDs的希望。摘要:再生医学技术是改变泌尿妇科临床模式的关键,从被动到预防。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
104
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​Current Opinion in Obstetrics and Gynecology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With eleven disciplines published across the year – including reproductive endocrinology, gynecologic cancer and fertility– every issue also contains annotated references detailing the merits of the most important papers.
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