Tatyanna Henderson, Karen L Christman, Marianna Alperin
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引用次数: 0
Abstract
Purpose of review: The etiology of urogynecologic conditions is multifactorial and complex. However, the inability of the host pelvic tissues to repair and regain their original function in response to various insults, including maternal birth injury or age-related changes in the endogenous regenerative potential, underlies the pathophysiology of the morbid pelvic floor disorders (PFDs). Regenerative medicine approaches are poised to not only treat but potentially prevent the development of these deleterious conditions, the prevalence of which continues to increase. We aim to highlight the existent work at the crossroads of urogynecology and regenerative medicine and to underscore areas in need for continued and novel investigations.
Recent findings: Regenerative medicine techniques, including stem cell therapies, extracellular vesicles, secretomes, platelet-rich plasma, laser-based interventions, and bioinductive acellular scaffolds, are being studied in the context of urogynecology, with many showing promise in revolutionizing prevention and treatment of PFDs by enhancing constructive tissue repair.
Summary: Regenerative medicine techniques hold the key to changing the clinical paradigm in Urogynecology from reactive to preventive.
期刊介绍:
Current Opinion in Obstetrics and Gynecology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With eleven disciplines published across the year – including reproductive endocrinology, gynecologic cancer and fertility– every issue also contains annotated references detailing the merits of the most important papers.