Prognostic value of tumor dissemination feature based on baseline 18F-FDG PET/CT in patients with newly diagnosed multiple myeloma.

IF 1.3 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine Communications Pub Date : 2025-09-25 DOI:10.1097/MNM.0000000000002059

Yue-Hong Guo, Ying Tian, Jing-Wei Huang, Ai-Jun Liu, Min-Fu Yang

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引用次数: 0

Abstract

Objectives: We evaluated the prognostic value of the new 18F-fluorodeoxyglucose PET/computer tomography (18F-FDG PET/CT) parameter reflecting the spread of the tumor, the largest distance between two lesions (Dmax), and compared the predictive power of the new parameter with other parameters in newly diagnosed multiple myeloma (NDMM) patients.

Methods: This retrospective study included 58 consecutive patients diagnosed with NDMM. 18F-FDG parameters [maximum standardized uptake value, metabolic tumor volume (MTV), and Dmax] and clinical data were analyzed for event-free survival (EFS). Univariate and multivariate analyses were performed using the Cox proportional hazards model, while survival outcomes were assessed via Kaplan-Meier curves.

Results: The median length of follow-up was 42 months (interquartile range, 18-62 months). Univariate analysis identified elevated serum calcium, elevated serum creatinine, MTV > 102.54 cm3, Dmax > 0.44 m, Dmax normalized by body height (Dmaxbh) > 0.27, Dmax normalized by body surface area (Dmaxbsa) > 0.24 m-1, and International Staging System stage as relevant prognostic factors for EFS (P < 0.1). Only Dmax > 0.44 m was found to be an independent prognostic factor for EFS on multivariate analysis (P = 0.047).

Conclusion: The new PET parameter of Dmax, reflecting myeloma dissemination, has been shown the independent prognostic value in NDMM patients. This preliminary finding warrants further investigation.

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基于基线18F-FDG PET/CT的肿瘤播散特征在新诊断多发性骨髓瘤患者中的预后价值

目的：评价反映肿瘤扩散、两个病灶之间最大距离（Dmax）的18F-FDG PET/CT （18F-FDG PET/CT）新参数对新诊断多发性骨髓瘤（NDMM）患者的预后价值，并将该新参数与其他参数的预测能力进行比较。方法：本回顾性研究纳入了58例连续诊断为NDMM的患者。对18F-FDG参数[最大标准化摄取值，代谢肿瘤体积（MTV）和Dmax]和临床数据进行无事件生存（EFS）分析。采用Cox比例风险模型进行单因素和多因素分析，通过Kaplan-Meier曲线评估生存结果。结果：中位随访时间为42个月（四分位数间距为18-62个月）。单因素分析发现血清钙升高、血清肌酐升高、MTV >02.54 cm3、Dmax > 0.44 m、身高归一化Dmax (Dmaxbh) > 0.27、体表面积归一化Dmax (Dmaxbsa) > 0.24 m-1、国际分期系统分期是EFS的相关预后因素(P 0.44 m是EFS的独立预后因素（P = 0.047）。结论：反映骨髓瘤播散的新的PET参数Dmax在NDMM患者中显示出独立的预后价值。这一初步调查结果值得进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Medicine Communications 医学-核医学

CiteScore

2.20

自引率

6.70%

发文量

212

审稿时长

3-8 weeks

期刊介绍： Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.