BOLD fMRI at 9.4T with 3D stack-of-spirals readouts.

IF 2.5 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-09-29 DOI:10.1007/s10334-025-01298-4

Alejandro Monreal-Madrigal, Denizhan Kurban, Desmond H Y Tse, Dimo Ivanov, Nicolas Boulant, Benedikt A Poser

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引用次数: 0

Abstract

Objective: To investigate the use of spiral readouts for sub-millimeter BOLD fMRI at 9.4T and to verify simulations of the BOLD point spread function (PSF) with functional experiments.

Materials and methods: Spiral readouts were evaluated through simulations and functional experiments to test their performance in sub-millimeter BOLD fMRI. Both spiral-out and spiral-in readout strategies were considered, with attention to echo time (TE) relative to T₂*.

Results: We confirmed that a TE shorter than T₂* can be employed for spiral-out readouts without compromising BOLD sensitivity. The use of shorter TE provided a reduced repetition time (TR), improved temporal signal-to-noise ratio (tSNR), and minimized off-resonance effects.

Discussion: Spiral-in readouts were found to be mainly useful for lower-resolution applications at ultra-high field (UHF). In contrast, segmented spiral-out readouts demonstrated strong potential for mesoscopic BOLD fMRI at ultra-high fields (> 7T).

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BOLD fMRI在9.4T时显示3D螺旋读数。

目的：探讨9.4T下亚毫米BOLD功能磁共振螺旋读数的应用，并通过功能实验验证BOLD点扩散函数（PSF）的模拟。材料和方法：通过模拟和功能实验评估螺旋读数，以测试其在亚毫米BOLD功能磁共振成像中的性能。考虑了螺旋出和螺旋入读出策略，并注意了相对于T2*的回波时间（TE）。结果：我们证实，在不影响BOLD灵敏度的情况下，可以使用短于T2*的TE进行螺旋输出读数。使用较短的TE可以减少重复时间（TR），提高时间信噪比（tSNR），并最大限度地减少非共振效应。讨论：螺旋读数主要用于超高场（UHF）的低分辨率应用。相比之下，在超高场（bbb7t）下，分段螺旋输出的读数显示了介观BOLD fMRI的强大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.