{"title":"Bronchodilator Response Assessed by Surface Respiratory Muscle EMG in Children.","authors":"Baiting He, Feng Li, Simin Liu, Lu Wang, Zhiqiang Chen, Qihua Zhu, Lishuang Wang, Shanfeng Liang, Miral Al-Sherif, Lihong Sun, Yuanming Luo","doi":"10.2147/JAA.S537519","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>An increase of ≥ 12% in forced expiratory volume in the first second (FEV<sub>1</sub>) after inhalation of bronchodilator indicates airway reversibility. However, it is difficult to measure FEV<sub>1</sub> in children. The aim of the study is to determine whether respiratory muscle electromyograms recorded from chest wall surface electrodes can be used to distinguish children with uncontrolled asthma from healthy subjects.</p><p><strong>Methods: </strong>Fourteen children with uncontrolled asthma [aged 6.1 (3 ~ 13) years] and 28 healthy children [aged 7.6 (3 ~ 13) years] were recruited. Uncontrolled asthma was defined as having poorly controlled symptoms, along with an increase in FEV<sub>1</sub> of at least 12%, or presenting with a wheezing symptom that improved after inhaling a bronchodilator. Diaphragm electromyogram (EMG<sub>di</sub>), parasternal intercostal EMG (EMG<sub>para</sub>), airflow, FEV<sub>1</sub>, and wheezing were recorded before and after inhalation of bronchodilator.</p><p><strong>Results: </strong>Good-quality EMG<sub>di</sub> and EMG<sub>para</sub> could be recorded in all subjects. However, 18 of 42 children could not perform the spirometer properly. Changes in EMG<sub>di</sub> [-24.6% (-43.5 ~ -12.4%) vs -0.1% (-13.2 ~ 16.9%), <i>p</i><0.001] and EMG<sub>para</sub> [-11.2% (-31.5 ~ 32.4%) vs -0.5% (-24.9 ~ 13.0%), <i>p</i><0.05] in children with asthma were, respectively, significantly larger than those in healthy subjects during bronchodilator response. The area under the receiver operating characteristic curves for the changes of EMG<sub>di</sub> and EMG<sub>para</sub> were 0.995 (95% CI 0.906 to 1.000) and 0.755 (95% CI 0.598 to 0.874).</p><p><strong>Conclusion: </strong>Surface respiratory muscle EMG could be feasible and useful to assess bronchodilator response to differentiate children with uncontrolled asthma from healthy subjects.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"1327-1335"},"PeriodicalIF":3.0000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474657/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asthma and Allergy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JAA.S537519","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: An increase of ≥ 12% in forced expiratory volume in the first second (FEV1) after inhalation of bronchodilator indicates airway reversibility. However, it is difficult to measure FEV1 in children. The aim of the study is to determine whether respiratory muscle electromyograms recorded from chest wall surface electrodes can be used to distinguish children with uncontrolled asthma from healthy subjects.
Methods: Fourteen children with uncontrolled asthma [aged 6.1 (3 ~ 13) years] and 28 healthy children [aged 7.6 (3 ~ 13) years] were recruited. Uncontrolled asthma was defined as having poorly controlled symptoms, along with an increase in FEV1 of at least 12%, or presenting with a wheezing symptom that improved after inhaling a bronchodilator. Diaphragm electromyogram (EMGdi), parasternal intercostal EMG (EMGpara), airflow, FEV1, and wheezing were recorded before and after inhalation of bronchodilator.
Results: Good-quality EMGdi and EMGpara could be recorded in all subjects. However, 18 of 42 children could not perform the spirometer properly. Changes in EMGdi [-24.6% (-43.5 ~ -12.4%) vs -0.1% (-13.2 ~ 16.9%), p<0.001] and EMGpara [-11.2% (-31.5 ~ 32.4%) vs -0.5% (-24.9 ~ 13.0%), p<0.05] in children with asthma were, respectively, significantly larger than those in healthy subjects during bronchodilator response. The area under the receiver operating characteristic curves for the changes of EMGdi and EMGpara were 0.995 (95% CI 0.906 to 1.000) and 0.755 (95% CI 0.598 to 0.874).
Conclusion: Surface respiratory muscle EMG could be feasible and useful to assess bronchodilator response to differentiate children with uncontrolled asthma from healthy subjects.
期刊介绍:
An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies.
Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.