Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021.

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Qinglin Yang, Zhuanmei Jin, Yongping Wang
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引用次数: 0

Abstract

Congenital musculoskeletal and limb deformities (CMLD) seriously affect the physical and mental health of patients, and pose great challenges to healthcare systems worldwide. We explored the specific situation and changes of incidence, prevalence, disability-adjusted life years rates, and mortality of CMLD in under-5 children from 1990 to 2021 in different groups, including different regions, periods, genders and socio-demographic indices (SDI), through corresponding analytical models. Overall, the global disease burden of CMLD in under-5 children has decreased from 1990 to 2021. The disease burden of CMLD in under-5 children varied significantly among different regions and countries, and there was a strong correlation between the corresponding burden of disease and the level of SDI. In addition, cross-country inequality analysis showed that while absolute inequalities in the disease burden of CMLD in under-5 children have improved, relative inequalities have worsened. It is essential to reduce the global health impact of CMLD by implementing targeted interventions to improve health care in underdeveloped areas.

1990年至2021年5岁以下儿童先天性肌肉骨骼和肢体畸形的全球、区域和国家负担和趋势:对2021年全球疾病负担研究的系统分析
先天性肌肉骨骼和肢体畸形(CMLD)严重影响患者的身心健康,对全球卫生保健系统构成巨大挑战。通过相应的分析模型,探讨1990 - 2021年不同地区、不同时期、不同性别、不同社会人口指数(SDI)等不同人群5岁以下儿童CMLD发病率、患病率、伤残调整生命年率、死亡率的具体情况及变化。总体而言,从1990年到2021年,5岁以下儿童的全球CMLD疾病负担有所下降。5岁以下儿童CMLD的疾病负担在不同地区和国家之间存在显著差异,相应的疾病负担与SDI水平之间存在较强的相关性。此外,跨国不平等分析表明,虽然5岁以下儿童CMLD疾病负担的绝对不平等有所改善,但相对不平等却恶化了。必须通过实施有针对性的干预措施来改善欠发达地区的卫生保健,从而减少CMLD对全球卫生的影响。
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来源期刊
Frontiers of Medicine
Frontiers of Medicine ONCOLOGYMEDICINE, RESEARCH & EXPERIMENTAL&-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
18.30
自引率
0.00%
发文量
800
期刊介绍: Frontiers of Medicine is an international general medical journal sponsored by the Ministry of Education of China. The journal is jointly published by the Higher Education Press and Springer. Since the first issue of 2010, this journal has been indexed in PubMed/MEDLINE. Frontiers of Medicine is dedicated to publishing original research and review articles on the latest advances in clinical and basic medicine with a focus on epidemiology, traditional Chinese medicine, translational research, healthcare, public health and health policies.
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