Particulate matter exposure and end-stage renal disease risk in IgA nephropathy.

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Yilin Chen, Huan Zhou, Siqing Wang, Lingqiu Dong, Yi Tang, Wei Qin
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引用次数: 0

Abstract

Long-term exposure to particulate matter has been increasingly implicated in the progression of chronic kidney disease (CKD). However, its impact on IgA nephropathy (IgAN), a leading cause of end-stage renal disease (ESRD), remains unclear. A total of 1768 IgAN patients, confirmed by renal biopsy were included in this cohort study. Long-term exposure to PM2.5 and PM10 was assessed using high-resolution satellite-based data from the China High Air Pollutants (CHAP) dataset. Cox proportional hazards models were used to estimate the associations between PM2.5 or PM10 and ESRD risk, adjusting for demographic, clinical, and biochemical covariates. Over a median follow-up of 3.63 years, 209 participants progressed to ESRD. Higher exposure to both PM2.5 and PM10 was significantly associated with an increased risk, with hazard ratios of 1.62 and 1.36 per 10 µg/m3 increase, respectively. A nonlinear dose-response relationship was observed, with risk increasing markedly beyond threshold levels. Trajectory modeling of prebaseline exposure identified a subgroup with persistently high and fluctuating particulate matter exposure that showed the highest risk. This study provides strong evidence that prolonged exposure to ambient particulate matter contributes to renal disease progression in individuals with IgAN.

IgA肾病患者的颗粒物暴露与终末期肾病风险
长期暴露于颗粒物与慢性肾脏疾病(CKD)进展的关系越来越密切。然而,它对终末期肾病(ESRD)的主要病因IgA肾病(IgAN)的影响尚不清楚。本队列研究共纳入1768例经肾活检证实的IgAN患者。使用来自中国高空气污染物(CHAP)数据集的高分辨率卫星数据评估PM2.5和PM10的长期暴露。Cox比例风险模型用于估计PM2.5或PM10与ESRD风险之间的关系,调整了人口统计学、临床和生化协变量。在中位3.63年的随访中,209名参与者进展为ESRD。暴露在PM2.5和PM10中与风险增加显著相关,风险比分别为每增加10微克/立方米1.62和1.36。观察到非线性剂量-反应关系,风险显著增加超过阈值水平。基线前暴露轨迹建模确定了一个亚组,其暴露水平持续高且波动,显示出最高的风险。本研究提供了强有力的证据,证明长期暴露于环境颗粒物有助于IgAN患者肾脏疾病的进展。
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来源期刊
Frontiers of Medicine
Frontiers of Medicine ONCOLOGYMEDICINE, RESEARCH & EXPERIMENTAL&-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
18.30
自引率
0.00%
发文量
800
期刊介绍: Frontiers of Medicine is an international general medical journal sponsored by the Ministry of Education of China. The journal is jointly published by the Higher Education Press and Springer. Since the first issue of 2010, this journal has been indexed in PubMed/MEDLINE. Frontiers of Medicine is dedicated to publishing original research and review articles on the latest advances in clinical and basic medicine with a focus on epidemiology, traditional Chinese medicine, translational research, healthcare, public health and health policies.
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