Predictive biomarkers for immunotherapy in nasopharyngeal carcinoma: from tumor microenvironment to macroenvironment.

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Saiwei Huang, Yelin Liang, Na Liu, Jun Ma
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引用次数: 0

Abstract

The introduction of PD-1 blockades to chemotherapy and radiotherapy has shown promising outcomes in patients with nasopharyngeal carcinoma, but anti-PD-1 therapies are only effective in a small proportion of patients, indicating the need for reliable predictive biomarkers of benefit from immunotherapy. Here, we summarized recent advances in immunotherapy for nasopharyngeal carcinoma and studies on potential predictors that correlated with treatment response or long-term survival after immunotherapy, including biomarkers in both the tumor microenvironment and the tumor macroenvironment. Some of these biomarkers have been validated as truly predictive of immunotherapy benefit using cohorts from randomized controlled trials, while others still require further validation of their predictive value. We also summarized the challenges and future directions of biomarker studies, hopefully facilitating the development of predictive biomarkers for immunotherapy that can eventually enter clinical practice.

鼻咽癌免疫治疗的预测性生物标志物:从肿瘤微环境到宏观环境。
在鼻咽癌患者化疗和放疗中引入PD-1阻断剂已显示出有希望的结果,但抗PD-1治疗仅对一小部分患者有效,这表明需要可靠的预测免疫治疗获益的生物标志物。在这里,我们总结了鼻咽癌免疫治疗的最新进展,以及与免疫治疗后治疗反应或长期生存相关的潜在预测因素的研究,包括肿瘤微环境和肿瘤宏观环境中的生物标志物。其中一些生物标志物已经通过随机对照试验的队列验证,可以真正预测免疫治疗的益处,而其他生物标志物的预测价值仍需要进一步验证。我们也总结了生物标志物研究的挑战和未来方向,希望能够促进免疫治疗预测生物标志物的发展,并最终进入临床实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers of Medicine
Frontiers of Medicine ONCOLOGYMEDICINE, RESEARCH & EXPERIMENTAL&-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
18.30
自引率
0.00%
发文量
800
期刊介绍: Frontiers of Medicine is an international general medical journal sponsored by the Ministry of Education of China. The journal is jointly published by the Higher Education Press and Springer. Since the first issue of 2010, this journal has been indexed in PubMed/MEDLINE. Frontiers of Medicine is dedicated to publishing original research and review articles on the latest advances in clinical and basic medicine with a focus on epidemiology, traditional Chinese medicine, translational research, healthcare, public health and health policies.
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