Orthodontic treatment and oral microbiota changes: a systematic review of oral dysbiosis revealed by 16S rRNA gene analysis.

IF 3.2

The Angle orthodontist Pub Date : 2025-08-29 DOI:10.2319/112724-978.1

Sara Di Nicolantonio, Serena Altamura, Davide Pietropaoli, Annalisa Monaco, Eleonora Ortu

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Abstract

Objectives: Evaluate the changes in oral microbiota linked to orthodontic treatment by analyzing the 16S rRNA gene.

Materials and methods: A total of 22 articles was included in the systematic review. The methodological quality of these studies was assessed using the Newcastle-Ottawa Scale for nonrandomized studies and the Risk of Bias tool for randomized studies.

Results: Orthodontic appliances significantly influenced the composition of oral microbiota. Specifically, fixed orthodontic appliances were linked to an increase in periodontopathogenic bacteria associated with various systemic diseases. In contrast, transparent aligners correlated with an increase in Streptococcus species.

Conclusions: In this study, we evaluated the changes in oral microbiota associated with orthodontic treatment by analyzing the 16S rRNA gene. Results revealed significant alterations in oral microbiota following orthodontic treatment; however, significant variability among studies prevents firm conclusions. Additional research is essential to clarify the effects on oral health.

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正畸治疗与口腔微生物群变化：16S rRNA基因分析揭示的口腔生态失调的系统综述。

目的：通过分析16S rRNA基因，评估口腔微生物群与正畸治疗相关的变化。材料与方法：本系统综述共纳入22篇文献。非随机研究采用纽卡斯尔-渥太华量表，随机研究采用偏倚风险工具，对这些研究的方法学质量进行评估。结果：正畸矫治器具对口腔菌群组成有显著影响。具体来说，固定正畸矫治器与与各种全身性疾病相关的牙周病致病菌的增加有关。相比之下，透明对准器与链球菌种类的增加相关。结论：在本研究中，我们通过分析16S rRNA基因来评估口腔微生物群与正畸治疗相关的变化。结果显示，正畸治疗后口腔微生物群有显著改变；然而，研究之间的显著差异阻碍了确定的结论。需要进一步的研究来阐明对口腔健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Angle orthodontist

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