Zihong Bai , Qingcui Huang , Xinya Li , Yitong Ling , Panwen Wu , Xiaxuan Huang , Shanyuan Tan , Jun Lyu
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引用次数: 0
Abstract
Background
Ischemic stroke remains a leading cause of disability and mortality worldwide, with pulmonary function emerging as a potential modifiable risk factor.
Methods
This study utilizes data from the UK Biobank to explore the association between peak expiratory flow (PEF), a simple and cost-effective marker of lung function, and ischemic stroke risk. A total of 307,827 participants were followed for a median of 13.8 years, with Cox regression models employed to examine the relationship between PEF and ischemic stroke incidence. Restricted cubic splines and mediation analysis were also used to investigate potential nonlinear relationships and the mediating role of inflammatory biomarkers, respectively.
Results
The results demonstrate that individuals with higher PEF levels exhibit a significantly reduced risk of ischemic stroke, with a 6.7 % and 10.4 % lower risk in the second and third tertiles of PEF, respectively, compared to the first tertile.Stratified analyses revealed a significant inverse association between PEF and stroke risk in former smokers (HR = 0.93, 95 %CI:0.88–0.98), with a non-significant trend in current smokers (HR = 0.92, 95 %CI:0.84–1.01). Subgroup analysis revealed heterogeneity by age, gender, hypertension, and diabetes status, highlighting differential effects. Mediation analysis suggested that inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio, partially mediate the association between lung function and stroke risk.
Conclusion
This study underscores the importance of monitoring lung function, particularly at the community level, as a preventive measure against ischemic stroke. Given the aging global population, early detection and management of declining lung function could play a crucial role in reducing stroke-related morbidity and mortality.
期刊介绍:
The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.