Association between prenatal exposures to per- and polyfluoroalkyl substances and early language development in the ECHO Cohort.

IF 3.9 3区医学 Q2 NEUROSCIENCES

Neurotoxicology Pub Date : 2025-09-25 DOI:10.1016/j.neuro.2025.103309

Patricia Cintora, Lesliam Quirós-Alcalá, Adaeze W Nzegwu, Sudhi Upadhyaya, Megan Woodbury, Sarah Dee Geiger, Rachel Morello-Frosch, Anne L Dunlop, Theresa M Bastain, Anne P Starling, Dana Dabelea, Carlos A Camargo, Pi-I Debby Lin, Rachel S Kelly, Assiamira Ferrara, Lisa A Croen, Thomas G O'Connor, June-Soo Park, Morgan Reynolds, Kurunthachalam Kannan, Susan L Schantz

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引用次数: 0

Abstract

Background/aim: The relationship between prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and child neurodevelopment remains inconclusive, and few studies have investigated associations of PFAS exposure with language development. This study drew on data from seven U.S.-based Environmental influences on Child Health Outcomes (ECHO) cohorts to investigate associations between prenatal PFAS exposures and language development in early childhood.

Methods: We quantified concentrations of four PFAS in maternal plasma or serum during pregnancy. Language development was assessed using the communication scale from the Ages & Stages Questionnaires, Third Edition (ASQ®-3) in children ages 1.5-5 years (n=1503) and the NIH Toolbox Picture Vocabulary Test (PVT) in children ages 3-5 years (n=399). Associations between single PFAS and language outcomes were examined in multivariable linear and logistic regression models. PFAS mixture was examined using quantile g-computation.

Results: Overall and in sex-specific analyses, we did not observe associations between individual PFAS biomarkers and language development. The PFAS mixture showed no significant associations with ASQ®-3 communication z-scores (ψ = -0.04; 95% CI: -0.86, 0.78) or PVT t-scores (ψ = 0.35; 95% CI: -1.14, 1.83). Sex-specific results showed a small but statistically significant negative association with ASQ®-3 communication scores in females (ψ = -0.46; 95% CI: -0.88, -0.05; p = 0.03) and positive, albeit not statistically significant, associations with PVT t-scores in males (ψ = 0.27; 95% CI: -1.84, 2.38) and females (ψ = 0.55; 95% CI: -1.81, 2.92).

Conclusions: Prenatal concentrations of individual PFAS or their mixture were not associated with ASQ®-3 communication domain scores or PVT t-scores.

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产前暴露于单氟烷基和多氟烷基物质与ECHO队列早期语言发育之间的关系

背景/目的：产前暴露于全氟烷基和多氟烷基物质（PFAS）与儿童神经发育之间的关系尚不明确，很少有研究调查PFAS暴露与语言发育的关系。本研究利用美国七个环境对儿童健康结果的影响（ECHO）队列的数据，调查产前PFAS暴露与儿童早期语言发展之间的关系。方法：测定妊娠期间母体血浆或血清中4种PFAS的浓度。在1.5-5岁儿童（n=1503）和3-5岁儿童（n=399）中使用《年龄与阶段问卷第三版》（ASQ®-3）中的交流量表评估语言发展。在多变量线性和逻辑回归模型中检验了单一PFAS与语言结果之间的关系。采用分位数g计算对PFAS混合物进行检测。结果：在总体和性别特异性分析中，我们没有观察到个体PFAS生物标志物与语言发育之间的关联。PFAS混合物与ASQ®-3沟通z-分数（ψ = -0.04; 95% CI: -0.86, 0.78）或PVT t-分数（ψ = 0.35; 95% CI: -1.14, 1.83）无显著相关性。性别差异结果显示，女性与ASQ®-3沟通得分呈负相关（ψ = -0.46, 95% CI: -0.88, -0.05; p = 0.03），男性与PVT t-得分呈正相关（ψ = 0.27, 95% CI: -1.84, 2.38），女性与PVT t-得分呈正相关（ψ = 0.55, 95% CI: -1.81, 2.92），但无统计学意义。结论：产前单个PFAS或其混合物浓度与ASQ®-3通信域评分或PVT t评分无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotoxicology 医学-毒理学

CiteScore

6.80

自引率

5.90%

发文量

161

审稿时长

70 days

期刊介绍： NeuroToxicology specializes in publishing the best peer-reviewed original research papers dealing with the effects of toxic substances on the nervous system of humans and experimental animals of all ages. The Journal emphasizes papers dealing with the neurotoxic effects of environmentally significant chemical hazards, manufactured drugs and naturally occurring compounds.