{"title":"Nonclassical Cannabinoid Receptors: Modern Concepts of Signal Transmission Functions and Mechanisms","authors":"M. G. Akimov, N. M. Gretskaya, V. V. Bezuglov","doi":"10.1134/S1068162025602502","DOIUrl":null,"url":null,"abstract":"<p>The review summarizes the current understanding of nonclassical cannabinoid receptors, their signaling mechanisms, and roles in physiological and pathological processes. Nonclassical receptors (GPR55, GPR18, GPR119, etc.) demonstrate tissue-specific expression, interaction with multiple G proteins, and ligand-dependent activation of signaling pathways. GPR55 is involved in the regulation of pain, angiogenesis, and oncogenesis; GPR18 modulates inflammation and metabolism; and GPR119 is promising for diabetes therapy. Their ability to heterodimerize has been identified, which complicates their pharmacological profile. Nonclassical cannabinoid receptors represent promising targets for the treatment of socially significant diseases (cancer, diabetes, and neurodegeneration). However, their context-dependent activity requires an in-depth study to develop selective drugs.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"51 5","pages":"1879 - 1908"},"PeriodicalIF":1.7000,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Bioorganic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1068162025602502","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The review summarizes the current understanding of nonclassical cannabinoid receptors, their signaling mechanisms, and roles in physiological and pathological processes. Nonclassical receptors (GPR55, GPR18, GPR119, etc.) demonstrate tissue-specific expression, interaction with multiple G proteins, and ligand-dependent activation of signaling pathways. GPR55 is involved in the regulation of pain, angiogenesis, and oncogenesis; GPR18 modulates inflammation and metabolism; and GPR119 is promising for diabetes therapy. Their ability to heterodimerize has been identified, which complicates their pharmacological profile. Nonclassical cannabinoid receptors represent promising targets for the treatment of socially significant diseases (cancer, diabetes, and neurodegeneration). However, their context-dependent activity requires an in-depth study to develop selective drugs.
期刊介绍：
Russian Journal of Bioorganic Chemistry publishes reviews and original experimental and theoretical studies on the structure, function, structure–activity relationships, and synthesis of biopolymers, such as proteins, nucleic acids, polysaccharides, mixed biopolymers, and their complexes, and low-molecular-weight biologically active compounds (peptides, sugars, lipids, antibiotics, etc.). The journal also covers selected aspects of neuro- and immunochemistry, biotechnology, and ecology.
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