Alessandra Fabi, Steven Hager, Laura Lourdes, Chiara Gandini, Elizabeth M Gavioli, Renuka Wakade, Enrico M Minnella, Marcello Allegretti
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引用次数: 0
Abstract
Background: Cancer-related fatigue (CRF) is a common symptom in patients with locally advanced or metastatic breast cancer (LA/M BC) receiving taxane-based chemotherapy (CT). CRF is commonly assessed as a subjective experience by patient questionnaires, such as the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue. The aim of this study was to extend validity of the FACIT-Fatigue and estimate clinically meaningful group-level differences in this patient population.
Materials and methods: This was a prospective, noninterventional, multinational study conducted in the United States and Italy from October 2021 to August 2023 in adult patients with LA/M BC eligible to receive cycle 1 of taxane-based CT. Patients completed a FACIT-Fatigue survey before starting CT and every 3 to 4 weeks for ∼16 weeks; a group of patients participated in a qualitative substudy to explore additional fatigue factors via semistructured, phone-based cognitive interviews.
Results: Sixty-two female patients with a mean (standard deviation) age of 55.5 (12.2) years were included. Baseline (visit 1) mean (95% confidence interval) FACIT-Fatigue score was 39.0 (36.8, 41.2), and fatigue worsened over time from 36.6 at visit 2 to 31.9 at visit 5. All FACIT-Fatigue items were relevant, with patients frequently reporting physical and psychological fatigue during treatment; the most highly relevant items were "I feel listless" and "I have to limit my social activity because I am tired." Triangulation of anchor-based, distribution-based, and qualitative-based methods determined a meaningful group-level difference of 2.4 points.
Conclusion: The FACIT-Fatigue survey includes items relevant to patients with LA/M BC on taxane-based CT.
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The Oncologist® is dedicated to translating the latest research developments into the best multidimensional care for cancer patients. Thus, The Oncologist is committed to helping physicians excel in this ever-expanding environment through the publication of timely reviews, original studies, and commentaries on important developments. We believe that the practice of oncology requires both an understanding of a range of disciplines encompassing basic science related to cancer, translational research, and clinical practice, but also the socioeconomic and psychosocial factors that determine access to care and quality of life and function following cancer treatment.
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