Tracing Five Decades of Psoriasis Pharmacotherapy: A Large-Scale Bibliometric Investigation with AI-Guided Terminology Normalization.

IF 4.8 3区 医学 Q2 CHEMISTRY, MEDICINAL
Pharmaceuticals Pub Date : 2025-09-21 DOI:10.3390/ph18091422
Ada Radu, Andrei-Flavius Radu, Gabriela S Bungau, Delia Mirela Tit, Paul Andrei Negru
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引用次数: 0

Abstract

Background/Objectives: Large-scale bibliometric assessments of psoriasis pharmacotherapy research remain limited despite significant research output in this rapidly evolving field. This study aimed to map the evolution of systemic psoriasis therapy research over five decades and demonstrate how systematic analysis of research trajectories can illuminate the transformation of specialized medical fields into central components of precision medicine. Methods: A comprehensive bibliometric analysis was conducted using Web of Science Core Collection as the single data source, examining 19,284 publications spanning 1975-2025. The methodology employed AI-enhanced terminology normalization for standardizing pharmaceutical nomenclature, VOSviewer version 1.6.20 for network visualization, and Bibliometrix package for temporal trend analysis and thematic evolution mapping. International collaboration networks, thematic evolution across three distinct periods (1975-2000, 2001-2010, 2011-2025), and citation impact patterns were systematically analyzed. Results: Four distinct developmental phases were identified, with publications growing from 9 articles in 1975 to 1638 in 2024. The United States dominated research output with 5959 documents, while Canada achieved the highest citation efficiency at 62.65 citations per document. Global collaboration encompassed 70 countries organized into four regional clusters, with a 28-nation Asia-Pacific-Africa-Middle East alliance representing the largest collaborative group. Citation impact peaked during 2001-2008, coinciding with revolutionary biological therapy introduction. Thematic evolution demonstrated systematic transformation from two foundational themes to nine specialized domains, ultimately consolidating into four core areas focused on targeted therapeutics and evidence-based methodologies. Keyword analysis demonstrated progression from basic immunological studies to sophisticated targeted interventions, evolving from tumor necrosis factor alpha inhibitors to contemporary interleukin-17/interleukin-23 pathway targeting and Janus kinase inhibitors. Conclusions: Over five decades, psoriasis therapeutics research has shifted from a niche dermatological discipline to a central model for innovation in immune-mediated diseases. This evolution illustrates how bibliometric approaches can capture the dynamics of scientific transformation, offering strategic insights for guiding pharmaceutical innovation, shaping research priorities, and informing precision medicine strategies across inflammatory conditions.

追踪五十年的牛皮癣药物治疗:人工智能引导术语规范化的大规模文献计量调查。
背景/目的:银屑病药物治疗研究的大规模文献计量评估仍然有限,尽管在这个快速发展的领域有大量的研究成果。本研究旨在描绘近50年来系统性银屑病治疗研究的演变,并展示研究轨迹的系统分析如何阐明专业医学领域向精准医学的核心组成部分的转变。方法:以Web of Science Core Collection为单一数据源,对1975-2025年间19284篇文献进行综合计量分析。该方法采用人工智能增强的术语规范化来标准化药物命名,VOSviewer 1.6.20版本用于网络可视化,Bibliometrix软件包用于时间趋势分析和专题演变映射。系统分析了国际合作网络、三个不同时期(1975-2000年、2001-2010年、2011-2025年)的专题演变以及引文影响模式。结果:发现了四个不同的发展阶段,发表文章从1975年的9篇增加到2024年的1638篇。美国的研究产出以5959篇论文占主导地位,而加拿大的引用效率最高,每篇论文被引用62.65次。全球合作包括分为四个区域集群的70个国家,由28个国家组成的亚太-非洲-中东联盟是最大的合作集团。引用影响在2001-2008年达到顶峰,与革命性生物疗法的引入相一致。主题演变展示了从两个基础主题到九个专业领域的系统转变,最终整合为四个核心领域,重点是靶向治疗和循证方法。关键词分析表明,从基础免疫学研究到复杂的靶向干预,从肿瘤坏死因子α抑制剂到当代白介素-17/白介素-23途径靶向和Janus激酶抑制剂的发展。结论:在过去的50年里,银屑病治疗研究已经从一个小众的皮肤病学学科转变为免疫介导疾病创新的中心模式。这一演变说明了文献计量学方法如何捕捉科学转变的动态,为指导药物创新、塑造研究重点和告知炎症条件下的精准医学策略提供战略见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmaceuticals
Pharmaceuticals Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
6.10
自引率
4.30%
发文量
1332
审稿时长
6 weeks
期刊介绍: Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details. Short communications are also accepted; therefore, there is no restriction on the maximum length of the papers.
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