Interactions of Extracts from Selected Plant Materials Supporting the Treatment of Alzheimer's Disease with Free Radicals-EPR and UV-Vis Studies.

IF 4.8 3区医学 Q2 CHEMISTRY, MEDICINAL

Pharmaceuticals Pub Date : 2025-09-21 DOI:10.3390/ph18091421

Damian Łomankiewicz, Barbara Pilawa, Ewa Chodurek, Magdalena Zdybel

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引用次数: 0

Abstract

Background/objectives: Interactions of infusions of Ginkgo biloba, ginseng, Yerba Mate, and green tea, with free radicals, were examined. The aim of these studies was to determine quenching of free radicals by the extracts from the selected plant raw materials that are useful in the treatment of Alzheimer's disease. Methods: The interactions were tested by an X-band (9.3 GHz) EPR spectroscopy and UV-Vis spectrophotometry. The model DPPH free radicals were used. The magnitude and changes with time of EPR and UV-Vis spectra of DPPH by the tested extracts were measured. Results: EPR and UV-Vis lines of DPPH free radicals decrease with increasing time of interactions of the extracts with DPPH, and after reaching the minimum value, it does not change with time. Ginseng infusion quenched free radicals the least. Ginkgo biloba extract quenches free radicals a little stronger than ginseng extract. Taking into account the tested extracts, Ginkgo biloba and ginseng extracts interact with free radicals less effectively compared to extracts of Yerba mate and green tea. Ginkgo biloba and ginseng extracts quench free radicals weaker than Yerba Mate and green tea extracts. Conclusions: Yerba Mate extract definitely had the strongest antioxidant properties. This extract quenches free radicals most effectively, what can be useful in the case of Alzheimer's disease. Given its strong antioxidant properties, green tea extract can also be particularly recommended in the case of Alzheimer's disease.

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支持自由基治疗阿尔茨海默病的选定植物提取物的相互作用- epr和UV-Vis研究。

背景/目的：研究了银杏叶、人参、马黛茶和绿茶与自由基的相互作用。这些研究的目的是确定在治疗阿尔茨海默病中有用的植物原料提取物对自由基的猝灭作用。方法：采用x波段（9.3 GHz） EPR光谱法和紫外可见分光光度法测定相互作用。采用DPPH自由基模型。测定了所测提取物的EPR值的大小和随时间的变化以及DPPH的紫外可见光谱。结果：DPPH自由基的EPR线和UV-Vis线随着与DPPH作用时间的增加而降低，达到最小值后不随时间变化。人参冲剂对自由基的抑制作用最小。银杏叶提取物对自由基的抑制作用强于人参提取物。考虑到测试的提取物，银杏叶和人参提取物与自由基的相互作用不如马黛茶和绿茶提取物有效。银杏叶和人参提取物对自由基的抑制作用弱于马黛茶和绿茶提取物。结论：马黛茶提取物具有较强的抗氧化性。这种提取物最有效地抑制自由基，对阿尔茨海默病很有用。鉴于其强大的抗氧化特性，绿茶提取物也可以特别推荐用于阿尔茨海默病。

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来源期刊

Pharmaceuticals Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.10

自引率

4.30%

发文量

1332

审稿时长

6 weeks

期刊介绍： Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details. Short communications are also accepted; therefore, there is no restriction on the maximum length of the papers.