Effects of Neighborhood Deprivation Index on Survival in Gastroesophageal Adenocarcinoma.

IF 2.7 4区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Healthcare Pub Date : 2025-09-13 DOI:10.3390/healthcare13182296

Sawyer Bawek, Mrinalini Ramesh, Malak Alharbi, Nour Nassour, Kayla Catalfamo, Han Yu, Beas Siromoni, Deepak Vadehra, Sarbajit Mukherjee

{"title":"Effects of Neighborhood Deprivation Index on Survival in Gastroesophageal Adenocarcinoma.","authors":"Sawyer Bawek, Mrinalini Ramesh, Malak Alharbi, Nour Nassour, Kayla Catalfamo, Han Yu, Beas Siromoni, Deepak Vadehra, Sarbajit Mukherjee","doi":"10.3390/healthcare13182296","DOIUrl":null,"url":null,"abstract":"Previous studies linked disadvantaged neighborhoods to poor cancer outcomes. The Neighborhood Deprivation Index (NDI) quantifies socioeconomic disadvantage, but its impact on gastroesophageal adenocarcinoma outcomes remains understudied. We conducted a retrospective analysis of 40,589 patients with esophageal or gastric adenocarcinoma from the SEER database (1996-2015), stratifying them by NDI: less disadvantaged (NDI < 60) and highly disadvantaged (NDI ≥ 60). Multivariate regression showed NDI ≥ 60 was independently associated with worse overall survival (OS) (HR 1.027, p = 0.017) and disease-specific survival (DSS) (HR 1.025, p = 0.04). Other predictors of poor OS and DSS included older age (≥60 years old), male sex, single marital status, lack of insurance, advanced stage/grade, and gastric tumor site. In contrast, Hispanic and non-Hispanic Black ethnicity, urban residence, and undergoing surgery were associated with better outcomes. Disadvantaged neighborhoods are linked to poorer survival in upper GI cancers, likely due to socioeconomic barriers. Addressing social determinants of health is crucial to reducing these disparities.","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 18","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469319/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Healthcare","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/healthcare13182296","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}

引用次数: 0

Abstract

Previous studies linked disadvantaged neighborhoods to poor cancer outcomes. The Neighborhood Deprivation Index (NDI) quantifies socioeconomic disadvantage, but its impact on gastroesophageal adenocarcinoma outcomes remains understudied. We conducted a retrospective analysis of 40,589 patients with esophageal or gastric adenocarcinoma from the SEER database (1996-2015), stratifying them by NDI: less disadvantaged (NDI < 60) and highly disadvantaged (NDI ≥ 60). Multivariate regression showed NDI ≥ 60 was independently associated with worse overall survival (OS) (HR 1.027, p = 0.017) and disease-specific survival (DSS) (HR 1.025, p = 0.04). Other predictors of poor OS and DSS included older age (≥60 years old), male sex, single marital status, lack of insurance, advanced stage/grade, and gastric tumor site. In contrast, Hispanic and non-Hispanic Black ethnicity, urban residence, and undergoing surgery were associated with better outcomes. Disadvantaged neighborhoods are linked to poorer survival in upper GI cancers, likely due to socioeconomic barriers. Addressing social determinants of health is crucial to reducing these disparities.

Abstract Image

查看原文本刊更多论文

邻域剥夺指数对胃食管腺癌患者生存的影响。

先前的研究将弱势社区与癌症预后差联系起来。邻里剥夺指数（NDI）量化了社会经济劣势，但其对胃食管腺癌结局的影响仍未得到充分研究。我们对来自SEER数据库（1996-2015）的40,589例食管癌或胃腺癌患者进行了回顾性分析，并按NDI进行了分层：轻度不利（NDI < 60）和高度不利（NDI≥60）。多因素回归显示，NDI≥60与较差的总生存期（OS）（HR 1.027, p = 0.017）和疾病特异性生存期（DSS）（HR 1.025, p = 0.04）独立相关。不良OS和DSS的其他预测因素包括年龄较大（≥60岁）、男性、单身婚姻状况、缺乏保险、晚期/分级和胃肿瘤部位。相比之下，西班牙裔和非西班牙裔黑人种族、城市居住和接受手术与更好的结果相关。弱势社区与上消化道癌症患者较差的生存率有关，可能是由于社会经济障碍。处理健康的社会决定因素对于缩小这些差距至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Healthcare Medicine-Health Policy

CiteScore

3.50

自引率

7.10%

发文量

审稿时长

47 days

期刊介绍： Healthcare (ISSN 2227-9032) is an international, peer-reviewed, open access journal (free for readers), which publishes original theoretical and empirical work in the interdisciplinary area of all aspects of medicine and health care research. Healthcare publishes Original Research Articles, Reviews, Case Reports, Research Notes and Short Communications. We encourage researchers to publish their experimental and theoretical results in as much detail as possible. For theoretical papers, full details of proofs must be provided so that the results can be checked; for experimental papers, full experimental details must be provided so that the results can be reproduced. Additionally, electronic files or software regarding the full details of the calculations, experimental procedure, etc., can be deposited along with the publication as “Supplementary Material”.