Felix Witte, Elke Weisshaar, Martin Metz, Steffen Koschmieder, Susanne Isfort, Andreas E Kremer, Martin Griesshammer, Svenja Royeck, Sonja Ständer, Claudia Zeidler
{"title":"Aquagenic Pruritus Questionnaire: Predicting Myeloproliferative Neoplasms in Patients with Aquagenic Pruritus.","authors":"Felix Witte, Elke Weisshaar, Martin Metz, Steffen Koschmieder, Susanne Isfort, Andreas E Kremer, Martin Griesshammer, Svenja Royeck, Sonja Ständer, Claudia Zeidler","doi":"10.1007/s13555-025-01548-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Aquagenic pruritus (AP) is an underrecognized condition in which patients perceive itch following contact with water on clinically non-lesional skin. AP is frequent in patients suffering from myeloproliferative neoplasms (MPN) such as polycythemia vera and may manifest several years prior to MPN diagnosis. To date, there is no validated patient-reported outcome measure (PROM) assessing AP and its association with MPN.</p><p><strong>Methods: </strong>In this multiphase study, eight questions relevant to AP were developed and validated in 77 patients with AP and 50 patients with chronic non-aquagenic pruritus (CP). After reduction to those questions relevant for distinguishing between AP with and without MPN, the resulting questionnaire was validated in 76 patients with AP (37 with MPN) and 76 with CP. The predictive power of the questionnaire's score was retrospectively tested in the first cohort.</p><p><strong>Results: </strong>Four key questions were identified as central to differentiating MPN in AP, forming the basis of the AP questionnaire (APQ). Sensitivity and specificity of the score reached 97.3% and 79.5%, respectively. The APQ classified five patients with AP with MPN who were diagnosed with MPN at a later stage.</p><p><strong>Conclusion: </strong>APQ is the first validated PROM for patients with AP, detecting a potential relationship to MPN with high sensitivity. APQ is a useful addition to standard of care in patients suffering from AP, potentially shortening the delay of MPN diagnosis.</p><p><strong>Trial registration: </strong>German Clinical Trials Registry, DRKS 00006075.</p>","PeriodicalId":11186,"journal":{"name":"Dermatology and Therapy","volume":" ","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13555-025-01548-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Aquagenic pruritus (AP) is an underrecognized condition in which patients perceive itch following contact with water on clinically non-lesional skin. AP is frequent in patients suffering from myeloproliferative neoplasms (MPN) such as polycythemia vera and may manifest several years prior to MPN diagnosis. To date, there is no validated patient-reported outcome measure (PROM) assessing AP and its association with MPN.
Methods: In this multiphase study, eight questions relevant to AP were developed and validated in 77 patients with AP and 50 patients with chronic non-aquagenic pruritus (CP). After reduction to those questions relevant for distinguishing between AP with and without MPN, the resulting questionnaire was validated in 76 patients with AP (37 with MPN) and 76 with CP. The predictive power of the questionnaire's score was retrospectively tested in the first cohort.
Results: Four key questions were identified as central to differentiating MPN in AP, forming the basis of the AP questionnaire (APQ). Sensitivity and specificity of the score reached 97.3% and 79.5%, respectively. The APQ classified five patients with AP with MPN who were diagnosed with MPN at a later stage.
Conclusion: APQ is the first validated PROM for patients with AP, detecting a potential relationship to MPN with high sensitivity. APQ is a useful addition to standard of care in patients suffering from AP, potentially shortening the delay of MPN diagnosis.
Trial registration: German Clinical Trials Registry, DRKS 00006075.
期刊介绍：
Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
