In Situ Evaluation of Drug Release and Water Ingress from 3D Printed Tablets Via Near Infrared and Raman Mapping

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Innovation Pub Date : 2025-09-26 DOI:10.1007/s12247-025-10068-7

Zoë J Whalley, Tom Mills, Richard Greenwood, Patrick Wray

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Abstract

3D printing of pharmaceuticals is an emerging field, which will have many exciting applications in the sphere of personalised medicine. The inherent advantages are that it offers manufacturing flexibility and platform versatility. However, there is limited mechanistic understanding of the dissolution behaviour of these novel dosage forms. In this study, Near Infrared (NIR) and Raman mapping techniques were used in conjunction with a custom dissolution flow cell to gather spatially resolved, real-time dissolution data of two geometries of 3D printed tablets. Caffeine was used as a model drug compound in a polymer filament. Two geometries of tablets were printed using Fused Filament Modelling (FFM); one solid tablet and one with vertical and horizontal channels. Chemical mapping facilitated simultaneous tracking of water ingress and drug distribution. The data obtained from this approach establishes a platform to assess the release mechanisms of many novel formulations and geometries of 3D printed pharmaceuticals to come.

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近红外和拉曼成像技术评价3D打印片剂的释药和入水过程

药物3D打印是一个新兴领域，在个性化医疗领域将有许多令人兴奋的应用。其固有的优势在于它提供了制造灵活性和平台的多功能性。然而，对这些新剂型的溶出行为的机理了解有限。在这项研究中，近红外（NIR）和拉曼映射技术与定制的溶出度流动池结合使用，收集了两种几何形状的3D打印片剂的空间分辨实时溶出度数据。咖啡因被用作聚合物纤维中的模型药物化合物。采用熔丝建模法（FFM）印制两种形状的片剂；一个是实心的，一个是有纵横通道的。化学作图有助于同时跟踪进水和药物分布。从这种方法获得的数据建立了一个平台，以评估许多新配方和3D打印药物的几何形状的释放机制。

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.