Synthesis of Radioiodinated Silica-Coated Magnetic Nanoparticles as SPECT/MR Dual-Modality Probe for Bone Imaging

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Innovation Pub Date : 2025-06-18 DOI:10.1007/s12247-025-10011-w

Noha A. Bayoumi

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引用次数: 0

Abstract

Purpose

A reliable imaging probe is essential for the accurate diagnosis of diseases and to support effective therapeutic decision-making. Different nanoparticles based multimodal probes have been studied for bone imaging. This work focuses on synthesizing of radiolabeled iron oxide magnetic nanoparticles as a promising dual modality bioprobe (SPECT/MR) for bone imaging.

Methods

In this work, silica coated magnetic nanoparticles (SiO₂@MNPs) were synthesized. Radioiodination of SiO₂@MNPs with iodine − 131 was performed via the Finkelstein reaction to produce a prospective radioiodinated MNPs for bone targeting.

Results

The radioiodinated NPs were obtained in high radiochemical purity (about 98.5 ± 0.5%) by magnet separation. The aqueous dispersion of the radioiodinated silica coated MNPs (¹³¹I-SiO₂@MNPs) exhibited adequate in-vitro stability and biocompatibility. Biodistribution study results after intravenous injection of (¹³¹I-SiO₂@MNPs) in normal mice revealed the high bone targeting efficiency of the radiolabeled NPs (C_max= 6± 0.5% ID/g at t_max= 2 h post injection). Magnetization properties measurements proved the preservation of the magnetic properties of SiO₂@MNPs after the iodination process retaining its effectiveness as MRI contrast agent.

Conclusion

Based on to the results of this study, ¹³¹I-SiO₂@MNPs could be considered as a promising candidate for SPECT/MR dual bone imaging.

Graphical Abstract

查看原文本刊更多论文

放射性碘化二氧化硅包覆磁性纳米颗粒作为骨成像SPECT/MR双模探针的合成

目的可靠的影像学探头对疾病的准确诊断和支持有效的治疗决策至关重要。不同的基于纳米颗粒的多模态探针已被研究用于骨成像。这项工作的重点是合成放射性标记的氧化铁磁性纳米颗粒作为一种有前途的双模生物探针（SPECT/MR）用于骨成像。方法合成二氧化硅包覆磁性纳米颗粒（SiO2@MNPs）。通过Finkelstein反应，用碘- 131对SiO2@MNPs进行放射性碘化，以产生用于骨靶向的放射性碘化MNPs。结果经磁分离得到的放射性碘化NPs具有较高的放射化学纯度（约98.5±0.5%）。放射性碘化二氧化硅包覆MNPs的水分散体（131I-SiO2@MNPs）表现出足够的体外稳定性和生物相容性。正常小鼠静脉注射（131I-SiO2@MNPs）后的生物分布研究结果显示，放射性标记NPs具有较高的骨靶向效率（注射后2h Cmax= 6±0.5% ID/g）。磁化性能测量证明了碘化处理后SiO2@MNPs的磁性能保持其作为MRI造影剂的有效性。结论基于本研究的结果，131I-SiO2@MNPs可被认为是SPECT/MR双骨成像的一个有希望的候选者。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.