The First Electrochemical Evaluation of Crizotinib Anticancer Drug Based on Carbon Felt Modified with Molecularly Imprinted Poly(pyrogallol)

IF 2.8 4区 化学 Q3 CHEMISTRY, PHYSICAL
Noor Alhuda Jabaar Hamzah, Mahmoud Roushani, Zahra Mirzaei Karazan
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引用次数: 0

Abstract

Crizotinib (CZT) is an anticancer drug confirmed for the treatment of lung cancer. It is a small-molecule inhibitor of tyrosine kinases. Therefore, selective and accurate measurement of CZT in human biological samples is highly significant. This research describes the first electrochemical sensor for CZT detection. Here, the design and fabrication of an electrochemical sensor based on molecularly imprinted polymer (MIP) is introduced. Employing the electropolymerization strategy, the MIP was synthesized on the carbon felt (CF) surface as the working electrode using pyrogallol (PG) as the functional monomer and CZT as the analyte. CF is the low-cost carbon-based material with high inherent surface area, porosity, and conductivity. There is linearity between current response and CZT concentration over a range from 0.005 to 800 nM with a detection limit (LOD) of 0.0016 nM. Assessment in the presence of similar compounds confirmed the superior selectivity of the sensor. Lastly, the sensor was applied for the detection of CZT in blood serum and urine samples with acceptable recovery. Furthermore, the introduced sensor’s performance was compared and verified through high-performance liquid chromatography (HPLC). This electrochemical sensor provides a promising possibility for practical applicability.

Graphical Abstract

分子印迹聚邻苯三酚改性碳毡对克唑替尼抗癌药的首次电化学评价
克唑替尼(CZT)是一种被证实可以治疗肺癌的抗癌药物。它是酪氨酸激酶的小分子抑制剂。因此,对人类生物样品中CZT的选择性和精确测量具有重要意义。本研究描述了第一个用于检测CZT的电化学传感器。本文介绍了一种基于分子印迹聚合物(MIP)的电化学传感器的设计与制造。采用电聚合策略,以邻苯三酚(PG)为功能单体,CZT为分析物,在碳毡(CF)表面作为工作电极合成了MIP。CF是一种低成本的碳基材料,具有较高的固有表面积、孔隙率和导电性。电流响应与CZT浓度在0.005 ~ 800 nM范围内呈线性关系,检出限为0.0016 nM。在类似化合物存在下的评估证实了该传感器的优越选择性。最后,将该传感器应用于血清和尿液样品中CZT的检测,回收率可接受。并通过高效液相色谱法(HPLC)对该传感器的性能进行了比较和验证。这种电化学传感器具有很好的实用化可能性。图形抽象
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来源期刊
Electrocatalysis
Electrocatalysis CHEMISTRY, PHYSICAL-ELECTROCHEMISTRY
CiteScore
4.80
自引率
6.50%
发文量
93
审稿时长
>12 weeks
期刊介绍: Electrocatalysis is cross-disciplinary in nature, and attracts the interest of chemists, physicists, biochemists, surface and materials scientists, and engineers. Electrocatalysis provides the unique international forum solely dedicated to the exchange of novel ideas in electrocatalysis for academic, government, and industrial researchers. Quick publication of new results, concepts, and inventions made involving Electrocatalysis stimulates scientific discoveries and breakthroughs, promotes the scientific and engineering concepts that are critical to the development of novel electrochemical technologies. Electrocatalysis publishes original submissions in the form of letters, research papers, review articles, book reviews, and educational papers. Letters are preliminary reports that communicate new and important findings. Regular research papers are complete reports of new results, and their analysis and discussion. Review articles critically and constructively examine development in areas of electrocatalysis that are of broad interest and importance. Educational papers discuss important concepts whose understanding is vital to advances in theoretical and experimental aspects of electrochemical reactions.
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