Justification of a protective container for a Tc-99m generator

IF 0.3 4区工程技术 Q4 NUCLEAR SCIENCE & TECHNOLOGY

Atomic Energy Pub Date : 2025-05-01 DOI:10.1007/s10512-025-01193-0

N. V. Kuznetsov, O. Yu. Kochnov, D. V. Stepchenkov, V. V. Fomichev

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引用次数: 0

Abstract

Background

In nuclear medicine, radiopharmaceutical drugs (RPDs) containing the technetium isotope Tc-99m are used to treat oncological diseases, such as brain, thyroid, and salivary gland cancer, as well as for diagnostic studies of the cardiovascular system. These RPDs are created using a molybdenum-technetium Tc-99m generator.

Aim

To determine the main parameters of complex protection for a designed transport container of a technetium generator for the production of RPDs in accordance with the GMP standard.

Materials and methods

Eighteen container material options were considered. To assess the protective characteristics of the container, we used the MicroShield v. 8.01 software. Transport indices and categories of all container options were determined taking into account the calculated rate of equivalent doses for gamma radiation from the Mo-99/Tc-99m sorption column and the nominal source activity.

Results

We have simulated an advanced protective container for the Tc-99m generator. The best protective characteristics are noted for the option combining tungsten and lead 2.5 and 3.5 cm thick, respectively.

Conclusion

This complex design of the protective container ensures the safe operation and transportation of the Tc-99m generator.

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Tc-99m发电机防护容器的论证

在核医学中，含有锝同位素Tc-99m的放射性药物（rpd）被用于治疗肿瘤疾病，如脑癌、甲状腺癌和唾液腺癌，以及心血管系统的诊断研究。这些rpd是使用钼-锝Tc-99m发生器制造的。目的根据GMP标准，确定设计的用于生产rpd的锝发生器运输容器复合防护的主要参数。材料与方法研究了18种容器材料。为了评估容器的防护特性，我们使用MicroShield v. 8.01软件。考虑到Mo-99/Tc-99m吸收柱的伽马辐射当量剂量计算率和标称源活度，确定了所有备选容器的运输指数和类别。结果模拟了一种用于Tc-99m发电机的先进防护容器。最好的保护特性是注意到选择结合钨和铅2.5和3.5 厘米厚分别。结论这种复杂的防护容器设计保证了Tc-99m发电机的安全运行和运输。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atomic Energy 工程技术-核科学技术

CiteScore

1.00

自引率

20.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Atomic Energy publishes papers and review articles dealing with the latest developments in the peaceful uses of atomic energy. Topics include nuclear chemistry and physics, plasma physics, accelerator characteristics, reactor economics and engineering, applications of isotopes, and radiation monitoring and safety.