Fibrinogen to albumin ratio (FAR) is associated with remote diffusion-weighted imaging lesions (RDWILs) and 1-month short-term outcomes in patients with acute intracerebral hemorrhage

IF 1.6 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Neurology and Neurosurgery Pub Date : 2025-09-23 DOI:10.1016/j.clineuro.2025.109167

Yuting Zhu , Teng Zhang , Yingge Wang , Xiaotian Xu

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引用次数: 0

Abstract

Aims

To investigate the associations between fibrinogen to albumin ratio (FAR) and remote diffusion-weighted imaging lesions (RDWILs) as well as 1-month short-term outcomes in patients with acute intracerebral hemorrhage (ICH).

Methods

A total of 229 consecutive patients with acute ICH were retrospectively included from our hospital between January 2022 and February 2024. RDWILs were defined as focal hyperintensities on diffusion-weighted imaging (DWI) while corresponding hypointensities on apparent diffusion coefficient (ADC), located ≥ 10 mm from the primary hemorrhage focus. FAR1 (within 24 h of admission) and FAR2 (3–7 days post-admission) were both collected. Primary analyses assessed relationships of FAR with RDWILs. Secondary analyses assessed the relationships of FAR with poor 1-month functional outcomes (defined as a modified Rankin Scale [mRS] score of 4–6).

Results

This study included 229 patients (mean age 63 years; 65.9 % male). The mean values of FAR1 and FAR2 were 7.1 and 8.1, respectively. RDWILs were detected in 19.7 % of patients, with 17.5 % having poor 1-month functional outcomes. After adjusting for key covariates, multivariate logistic regression revealed: FAR1 (OR=1.137, 95 %CI:1.057–1.223, p < 0.05) and FAR2 (OR=1.198, 95 %CI:1.088–1.320, p < 0.05) independently associated with RDWILs; FAR2 independently associated with poor 1-month outcomes (OR=1.276, 95 %CI:1.109–1.469, p < 0.05).

Conclusions

We found FAR independently correlates with RDWILs and poor 1-month outcomes in acute ICH patients, with its underlying mechanism to be further explored.

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急性脑出血患者纤维蛋白原与白蛋白比（FAR）与远端弥散加权成像病变（RDWILs）和1个月短期预后相关

目的探讨急性脑出血（ICH）患者纤维蛋白原/白蛋白比（FAR）与远端弥散加权成像病变（RDWILs）及1个月短期预后的关系。方法回顾性分析我院2022年1月至2024年2月229例急性脑出血患者。RDWILs定义为扩散加权成像（DWI）上的病灶高信号，而表观扩散系数（ADC）上的相应低信号，位于距离原发出血病灶≥ 10 mm处。FAR1（入院后24 h内）和FAR2（入院后3-7天）均采集。初步分析评估了FAR与rdwill的关系。二次分析评估FAR与1个月功能预后差的关系（定义为修改的Rankin量表[mRS]评分为4-6）。结果229例患者（平均年龄63岁，男性占65.9% %）。FAR1和FAR2的平均值分别为7.1和8.1。19.7% %的患者检测到RDWILs， 17.5% %的患者1个月功能预后较差。调整关键协变量后，多因素logistic回归显示：FAR1 （OR=1.137, 95 %CI: 1.057-1.223, p <； 0.05）和FAR2 （OR=1.198, 95 %CI: 1.088-1.320, p <； 0.05）与rdwls独立相关；FAR2与1个月不良预后独立相关（OR=1.276, 95 %CI: 1.109-1.469, p <； 0.05）。结论：我们发现FAR与急性脑出血患者的RDWILs和1个月预后不良独立相关，其潜在机制有待进一步探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.