HIGH WAITING LIST MORTALITY AMONG LIVER TRANSPLANT CANDIDATES WITH ALCOHOL-RELATED LIVER DISEASE: A 10-YEAR COHORT FROM A BRAZILIAN TERTIARY CENTER

IF 4.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-09-01 DOI:10.1016/j.aohep.2025.102025

Guilherme Fontanini Massote , Roberta Araújo Chaves , Verena da Silva Ayub , Fernanda Souza Fernandes , Ajith Sankarankutty Kumar

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Abstract

Introduction and Objectives

Alcohol-related liver disease (ALD) is a leading cause of cirrhosis-related mortality and a common indication for liver transplantation. This study aimed to assess the impact and characteristics of ALD in liver transplant candidates at a tertiary center in Brazil.

Patients and Methods

This retrospective study included the medical records of patients listed for liver transplantation between 2009 and 2019 at a tertiary hospital. We evaluated the proportion of ALD as an indication, clinical and epidemiological profiles, waiting list mortality, and patterns of alcohol consumption and abstinence in patients with ALD.

Results

Among the 583 patients, 243 (41.7%) had ALD. This etiology was the most frequent among both non-transplanted (45.5%) and transplanted (38.4%) patients. In the transplanted group, ALD patients were predominantly male and smokers (p<0.001). The overall waiting list mortality rate was 70.2%, with ALD accounting for 43% of the deaths. Among the 118 transplanted patients with an alcohol-related component, data on alcohol consumption were available for 92. The mean daily alcohol intake was 133.1 g, with a mean abstinence duration of 4.9 years before transplantation.

Conclusions

ALD was the most frequent indication for liver transplantation in this cohort and was associated with high mortality on the waiting list. These findings highlight the need for the early identification and management of patients with harmful alcohol use.

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酒精相关性肝病肝移植候选者的高等待名单死亡率：来自巴西三级中心的10年队列研究

酒精相关性肝病（ALD）是肝硬化相关死亡的主要原因，也是肝移植的常见适应症。本研究旨在评估ALD对巴西三级中心肝移植候选人的影响和特征。患者与方法本回顾性研究纳入了2009 - 2019年某三级医院肝移植患者的病历。我们评估了ALD作为指征的比例、临床和流行病学概况、等候名单死亡率以及ALD患者的饮酒和戒酒模式。结果583例患者中有243例（41.7%）为ALD。这种病因在未移植（45.5%）和移植（38.4%）患者中最为常见。在移植组中，ALD患者主要是男性和吸烟者（p<0.001）。整体轮候死亡率为70.2%，ALD占死亡人数的43%。在118例有酒精相关成分的移植患者中，有92例可获得饮酒数据。移植前平均每日酒精摄入量为133.1 g，平均戒酒时间为4.9年。结论sald是该队列中最常见的肝移植指征，且与等待名单上的高死亡率相关。这些发现强调了早期识别和管理有害酒精使用患者的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.