Increased genotoxic damage in Sicilian donkeys reared in different conditions of air quality

IF 2.5 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Mutation research. Genetic toxicology and environmental mutagenesis Pub Date : 2025-09-26 DOI:10.1016/j.mrgentox.2025.503899

Emanuele D'Anza , Ilaria Cascone , Flavio Luongo , Sara Albarella , Francesca Ciotola , Luigi Liotta , Vincenzo Peretti

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引用次数: 0

Abstract

This study investigates chromosomal damage in donkeys to assess the impact of long-term exposure to different concentrations of environmental genotoxic agents, which pose health risks to animals and humans by promoting DNA breaks. The genotoxic damage was assessed through aneuploidy, chromosomal aberrations (CAs), and sister chromatid exchanges (SCEs) tests in donkeys, crossbred Ragusano and Grigio Siciliano breeds, from three areas in the Sicily region (Italy) with different levels of air pollution. Donkeys from areas with higher concentrations of fine particulate matter and nitrogen dioxide showed significantly elevated levels of aneuploidy and chromosomal abnormalities compared to those from less polluted areas. These findings provide the first evidence in donkeys of the combined effects of long-term exposure to airborne pollutants on genomic stability. This study reinforces the potential use of donkeys as effective biomonitoring organisms for evaluating environmental health risks and genotoxic damage under different pollution conditions.

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不同空气质量条件下饲养的西西里驴基因毒性损伤增加

本研究调查了驴的染色体损伤，以评估长期暴露于不同浓度的环境遗传毒性物质的影响，这些物质通过促进DNA断裂对动物和人类构成健康风险。通过非整倍体、染色体畸变（CAs）和姐妹染色单体交换（SCEs）试验，对来自意大利西西里岛地区不同空气污染水平地区的驴、拉古萨诺（Ragusano）和西西里灰驴（Grigio Siciliano）杂交品种进行基因毒性损害评估。来自细颗粒物和二氧化氮浓度较高地区的驴与来自污染较轻地区的驴相比，非整倍体和染色体异常水平明显升高。这些发现为长期暴露于空气污染物对基因组稳定性的综合影响提供了第一个证据。本研究强调了驴作为评估不同污染条件下环境健康风险和基因毒性损害的有效生物监测生物的潜力。

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来源期刊

Mutation research. Genetic toxicology and environmental mutagenesis 生物-毒理学

CiteScore

3.80

自引率

5.30%

发文量

审稿时长

105 days

期刊介绍： Mutation Research - Genetic Toxicology and Environmental Mutagenesis (MRGTEM) publishes papers advancing knowledge in the field of genetic toxicology. Papers are welcomed in the following areas: New developments in genotoxicity testing of chemical agents (e.g. improvements in methodology of assay systems and interpretation of results). Alternatives to and refinement of the use of animals in genotoxicity testing. Nano-genotoxicology, the study of genotoxicity hazards and risks related to novel man-made nanomaterials. Studies of epigenetic changes in relation to genotoxic effects. The use of structure-activity relationships in predicting genotoxic effects. The isolation and chemical characterization of novel environmental mutagens. The measurement of genotoxic effects in human populations, when accompanied by quantitative measurements of environmental or occupational exposures. The application of novel technologies for assessing the hazard and risks associated with genotoxic substances (e.g. OMICS or other high-throughput approaches to genotoxicity testing). MRGTEM is now accepting submissions for a new section of the journal: Current Topics in Genotoxicity Testing, that will be dedicated to the discussion of current issues relating to design, interpretation and strategic use of genotoxicity tests. This section is envisaged to include discussions relating to the development of new international testing guidelines, but also to wider topics in the field. The evaluation of contrasting or opposing viewpoints is welcomed as long as the presentation is in accordance with the journal''s aims, scope, and policies.