CHARACTERIZATION OF PATIENTS CO-INFECTED WITH HEPATITIS C AND HIV IN THE NORTH REGION OF BRAZ

IF 4.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-09-01 DOI:10.1016/j.aohep.2025.102041

Isabelle Cristine de Jesus Macedo , Aline Alves da Silva , Elton Carlos de Almeida , João Vitor da Mota Silva , Carla Francisca dos Santos Cruz , Ana Paula Maciel Gurski , Ana Monica de Mello , Nathália da Silva Cruz , Mário Peribanez Gonzalez , Jose Nilton Neris Gomes , Leonardo Carrara Matsuura

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Abstract

Introduction and Objectives

Patients co-infected with Human Immunodeficiency Virus (HIV) and hepatitis C virus (HCV) are at higher risk of unfavorable outcomes, such as accelerated development of liver fibrosis and cirrhosis, as well as increased morbidity and mortality.

To describe the profile of patients co-infected with hepatitis C and HIV in the North region of Brazil between 2013 and 2023.

Materials and Methods

A descriptive, cross-sectional study using data from the Notifiable Diseases Information System (Sinan) for the period from 2013 to 2023. The variables analyzed were sex, race, and education level. Descriptive statistical analysis was performed to characterize the profile of the cases.

Results

A total of 420 cases of co-infection with hepatitis C and HIV were identified. The majority were male (69.0%) and self-declared as "pardo" (brown/mixed-race) (81.4%). Regarding education level, 26.2% of the records were unknown; among the available data, those with complete high school education (19.0%) and 5 to 8 incomplete years of study (18.1%) stood out. In terms of geographical distribution, Amazonas had the highest proportion of cases (38.8%), followed by Pará (29.5%) and Rondônia (16.7%).

Conclusions

The data indicate a predominant profile of co-infection among men, "pardo" individuals, and those with low education levels, with a concentration in the state of Amazonas. These findings reinforce the need for specific prevention, diagnosis, and care strategies aimed at the most vulnerable populations in the North region.

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巴西北部地区丙型肝炎和HIV合并感染患者的特征分析

人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）合并感染的患者出现不良结果的风险更高，如肝纤维化和肝硬化的加速发展，以及发病率和死亡率的增加。描述2013年至2023年巴西北部地区丙型肝炎和艾滋病毒合并感染患者的概况。材料与方法一项描述性、横断面研究，使用2013年至2023年的法定疾病信息系统（思南）数据。分析的变量包括性别、种族和教育水平。进行描述性统计分析，以确定病例的特征。结果共检出丙型肝炎和HIV合并感染病例420例。大多数是男性（69.0%），自称为“pardo”（棕色/混血儿）（81.4%）。教育程度不详者占26.2%；在现有数据中，完成高中教育（19.0%）和5至8年未完成学业（18.1%）的人比较突出。从地理分布来看，亚马逊地区的病例比例最高（38.8%），其次是paras（29.5%）和Rondônia（16.7%）。结论：该数据表明，男性、“pardo”个体和低教育水平人群的合并感染占主导地位，并集中在亚马逊州。这些发现加强了针对北部地区最脆弱人群制定具体预防、诊断和护理战略的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.