PREVALENCE OF COVERT HEPATIC ENCEPHALOPATHY IN PATIENTS WITH COMPENSATED LIVER CIRRHOSIS

IF 4.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-09-01 DOI:10.1016/j.aohep.2025.102027

Oscar Suazo , Aissatou Sow , Susana Borges , Marlén Castellanos , Sila M. Gonzales , Danay Guerrero , Mirtha Infante Velasquez , Yusimik Román

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引用次数: 0

Abstract

Introduction and Objectives

Covert hepatic encephalopathy (CHE) is a complication that affects the quality of life and prognosis of cirrhotic patients. It is identified through appropriate neuropsychological tests. Objectives: To determine the prevalence of CHE in patients with compensated liver cirrhosis using the Psychometric Hepatic Encephalopathy Score (PHES) and its association with selected clinical factors.

Materials and Methods

A descriptive, cross-sectional study was conducted at the Institute of Gastroenterology in Havana, Cuba, between March 2023 and December 2024. Sixty-five patients with defined selection criteria were included. The prevalence of CHE was calculated according to the total PHES, using normality tables for the Cuban population. PHES scores and laboratory parameters were compared, and the association with sex, age, education, and etiology was explored between the groups with and without EHE.

Results

The prevalence of EHE was 32.3% (n=21). Differences were found between groups with and without EHE in the total PHES (p<0.001) and in each of its components. No association was demonstrated between age, sex, educational level, and etiology of cirrhosis with EHE, nor was there statistical significance between ALAT (p=0.68), ASAT (p=0.90), albumin (p=0.65), and platelet count (p=0.63). Age >60 years, male sex, viral etiology, low educational level, and liver function did not influence the diagnosis of EHE.

Conclusions

The PHES is an objective tool that allowed the identification of EHE in the context studied, which is relevant for the early management of compensated cirrhosis.

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代偿性肝硬化患者隐匿性肝性脑病的患病率

隐蔽性肝性脑病（CHE）是一种影响肝硬化患者生活质量和预后的并发症。它是通过适当的神经心理学测试来确定的。目的：利用肝性脑病心理测量评分（PHES）确定代偿性肝硬化患者中CHE的患病率及其与选定临床因素的关系。材料与方法一项描述性横断面研究于2023年3月至2024年12月在古巴哈瓦那胃肠病学研究所进行。纳入了65例具有明确选择标准的患者。利用古巴人口的正态表，根据公共卫生指数的总数计算了古巴疾病的患病率。比较EHE组和非EHE组的PHES评分和实验室参数，并探讨其与性别、年龄、教育程度和病因的关系。结果EHE患病率为32.3% （n=21）。在有EHE和没有EHE的组之间，总PHES （p<0.001）及其每个组成部分存在差异。年龄、性别、受教育程度、肝硬化病因与EHE无相关性，ALAT （p=0.68）、ASAT （p=0.90）、白蛋白（p=0.65）、血小板计数（p=0.63）之间无统计学意义。年龄60岁、男性、病毒病因、低文化程度、肝功能对EHE的诊断无影响。结论PHES是一种客观的工具，可以在研究的背景下识别EHE，这与代偿性肝硬化的早期治疗有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.