Metal artifact reduction and contrast agent performance as a function of source spectral shape.

IF 3.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Jacob D Aubrey, Emmett P Perkinson, Ge Wang, Peter J Bonitatibus
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引用次数: 0

Abstract

Objective.Empirically map the x-ray source of a Medipix All Resolution Scanner (MARS) photon counting CT (PCCT) with Cu and Sn pre-filters, assess metal artifact reduction (MAR) capabilities of these pre-filters, and measure pre-filtration impact on contrast performance (CP) of FDA approved iopromide and experimental tantalum oxide nanoparticles (TaOxNPs).Approach.The x-ray source of a MARS-PCCT system was empirically mapped with no pre-filtration, seven Cu filters (0.3-2.1 mm), and seven Sn filters (0.15-1.05 mm). A phantom with inserts containing water, lipid, iopromide, TaOxNPs, and metal was scanned with no pre-filtration and Cu and Sn pre-filters. Insert noise, signal, contrast-to-pooled-noise ratio (CPNR), and a fast Fourier transform artifact metric (FFTAM) were calculated for each filter to quantify MAR and CP.Main results.Thick filters for Cu and Sn shifted mean energy of the unfiltered x-ray source (47.9 keV) by 19.2 and 23.4 keV, respectively. Thick filtration, 2.1 mm Cu and 0.6 mm Sn, greatly reduced noise (up to 74%) and FFTAM (up to 71%) for all inserts and energy bins. Thin filtration, 0.3 mm Cu and 0.15 mm Sn, also reduced noise (up to 47%) and FFTAM (up to 41%). In most cases, iopromide lost significant contrast (up to 50%). TaOxNPs also lost contrast, though to a lesser extent (up to 38%). Pre-filtration improved image efficacy (i.e. CPNR), especially for TaOx(up to 61%).Significance.By empirically mapping the source spectrum of a MARS-PCCT system with pre-filters, valuable information was gathered about photon flux distribution and detector artifacts; these findings will prove insightful for applications such as energy binning for effective material decomposition. Furthermore, this information will potentially guide clinical MAR development, most notably for the MARS Extremity 5 × 120 recently deployed for first-in-human trials. Lastly, TaOxNPs were shown to be more compatible than iopromide with spectral shaping.

金属伪影还原和造影剂性能作为源光谱形状的函数。
目的:对具有Cu和Sn预过滤器的Medipix全分辨率扫描仪(MARS)光子计数CT (PCCT)的x射线源进行经验映射,评估这些预过滤器的金属伪影减少(MAR)能力,并测量预过滤对FDA批准的碘丙胺和实验性氧化钽纳米颗粒(TaOx NPs)的对比性能(CP)的影响。方法:对MARS-PCCT系统的x射线源进行了无预过滤、7个Cu滤光片(0.3-2.1 mm)和7个Sn滤光片(0.15-1.05 mm)的经验映射。在没有预过滤和Cu和Sn预过滤的情况下,对植入物含有水、脂质、碘酰、TaOx NPs和金属的假体进行扫描。计算了每个滤波器的插入噪声、信号、对比-池噪声比(CPNR)和快速傅立叶变换伪指标(FFTAM),以量化MAR和cp。主要结果:Cu和Sn的厚滤波器使未滤波的x射线源(47.9 keV)的平均能量分别偏移19.2和23.4 keV。厚过滤,2.1毫米铜和0.6毫米锡,大大降低噪音(高达74%)和FFTAM(高达71%)的所有插入和能源箱。薄过滤,0.3 mm Cu和0.15 mm Sn,也降低了噪音(高达47%)和FFTAM(高达41%)。在大多数情况下,碘丙胺明显失去造影剂(高达50%)。TaOx NPs也失去了对比,尽管程度较轻(高达38%)。预过滤提高了图像效率(即CPNR),特别是对TaOx(高达61%)。意义:利用预滤波器对MARS-PCCT系统的源光谱进行经验性映射,收集了有关光子通量分布和探测器伪影的有价值信息;这些发现将被证明具有洞察力的应用,如有效分解材料的能量箱。此外,这些信息将潜在地指导临床MAR的发展,最值得注意的是最近首次部署在人体试验中的MARS Extremity 5X120。最后,TaOx NPs与光谱整形的相容性优于碘丙胺。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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