Epidemiological and Clinical Characteristics of Acute Stroke in a Multi-Ethnic South Asian Population.

IF 3 Q2 CLINICAL NEUROLOGY
Kim H Tran, Naveed Akhtar, Yahia Imam, Md Giass Uddin, Sujatha Joseph, Deborah Morgan, Blessy Babu, Ryan Ty Uy, Ashfaq Shuaib
{"title":"Epidemiological and Clinical Characteristics of Acute Stroke in a Multi-Ethnic South Asian Population.","authors":"Kim H Tran, Naveed Akhtar, Yahia Imam, Md Giass Uddin, Sujatha Joseph, Deborah Morgan, Blessy Babu, Ryan Ty Uy, Ashfaq Shuaib","doi":"10.3390/neurolint17090140","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Stroke is one of the leading causes of death and disability worldwide. Compared to developed countries, the prognosis of stroke is less favourable in developing countries. The objective of this study is to identify inter-ethnic variation in risk profiles and stroke outcomes amongst Bangladeshi, Indian, Nepalese, Pakistani, and Sri Lankan expatriates living in Qatar.</p><p><strong>Methods: </strong>Data from the Qatar Stroke Registry were retrospectively analyzed from April 2014 to June 2025. A total of 8825 patients were included. The chi-square test was used to analyze sociodemographic variables, while the Kruskal-Wallis test was used to analyze continuous variables. Post hoc analysis was performed. Multivariate logistic regression and multivariate multiple regression were used to identify the predictors associated with poor clinical outcomes and mortality at 90 days.</p><p><strong>Results: </strong>Ischemic stroke was the predominant stroke type in all groups, with Nepalese patients presenting with stroke at a younger age, whilst Pakistanis tended to be older (<i>p</i> < 0.001). In terms of stroke outcomes, Nepalese patients had the highest proportion of a poor functional outcome at 90 days as well as NIHSS at discharge (<i>p</i> < 0.05). However, Bangladeshis had the highest proportion of mortality at 90 days compared to the other cohorts. Multivariable logistic regression revealed that undiagnosed dyslipidemia, Nepalese ethnicity, and moderate and severe NIHSS admission scores were independent predictors of a poor functional outcome at 90 days, whilst male sex and prior antidiabetic therapy were protective factors (<i>p</i> < 0.001). In terms of mortality at 90 days, only a severe NIHSS admission score (>10) was a significant predictor (<i>p</i> < 0.001). A severe NIHSS admission score was also the only predictive factor of mortality and poor functional outcome at 90 days (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>There was a significant variation in stroke presentation and outcomes among South Asian subpopulations in Qatar, suggesting the importance of tailored public health strategies as a uniform approach to stroke care is insufficient for this diverse population.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 9","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472970/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/neurolint17090140","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Stroke is one of the leading causes of death and disability worldwide. Compared to developed countries, the prognosis of stroke is less favourable in developing countries. The objective of this study is to identify inter-ethnic variation in risk profiles and stroke outcomes amongst Bangladeshi, Indian, Nepalese, Pakistani, and Sri Lankan expatriates living in Qatar.

Methods: Data from the Qatar Stroke Registry were retrospectively analyzed from April 2014 to June 2025. A total of 8825 patients were included. The chi-square test was used to analyze sociodemographic variables, while the Kruskal-Wallis test was used to analyze continuous variables. Post hoc analysis was performed. Multivariate logistic regression and multivariate multiple regression were used to identify the predictors associated with poor clinical outcomes and mortality at 90 days.

Results: Ischemic stroke was the predominant stroke type in all groups, with Nepalese patients presenting with stroke at a younger age, whilst Pakistanis tended to be older (p < 0.001). In terms of stroke outcomes, Nepalese patients had the highest proportion of a poor functional outcome at 90 days as well as NIHSS at discharge (p < 0.05). However, Bangladeshis had the highest proportion of mortality at 90 days compared to the other cohorts. Multivariable logistic regression revealed that undiagnosed dyslipidemia, Nepalese ethnicity, and moderate and severe NIHSS admission scores were independent predictors of a poor functional outcome at 90 days, whilst male sex and prior antidiabetic therapy were protective factors (p < 0.001). In terms of mortality at 90 days, only a severe NIHSS admission score (>10) was a significant predictor (p < 0.001). A severe NIHSS admission score was also the only predictive factor of mortality and poor functional outcome at 90 days (p < 0.05).

Conclusions: There was a significant variation in stroke presentation and outcomes among South Asian subpopulations in Qatar, suggesting the importance of tailored public health strategies as a uniform approach to stroke care is insufficient for this diverse population.

南亚多民族人群急性脑卒中的流行病学和临床特征。
目的:中风是世界范围内导致死亡和残疾的主要原因之一。与发达国家相比,发展中国家中风的预后较差。本研究的目的是确定居住在卡塔尔的孟加拉国人、印度人、尼泊尔人、巴基斯坦人和斯里兰卡人在风险概况和中风结局方面的种族差异。方法:回顾性分析卡塔尔卒中登记处2014年4月至2025年6月的数据。共纳入8825例患者。社会人口学变量分析采用卡方检验,连续变量分析采用Kruskal-Wallis检验。进行事后分析。采用多变量logistic回归和多变量多元回归来确定与不良临床结果和90天死亡率相关的预测因素。结果:缺血性卒中是所有组中主要的卒中类型,尼泊尔患者出现卒中的年龄较小,而巴基斯坦患者倾向于年龄较大(p < 0.001)。在卒中结局方面,尼泊尔患者在90天的功能不良结局和出院时NIHSS的比例最高(p < 0.05)。然而,与其他队列相比,孟加拉国人在90天内的死亡率最高。多变量logistic回归显示,未确诊的血脂异常、尼泊尔种族、中度和重度NIHSS入院评分是90天功能不良结局的独立预测因素,而男性和既往抗糖尿病治疗是保护因素(p < 0.001)。就90天死亡率而言,只有严重的NIHSS入院评分(bbb10)是显著的预测因子(p < 0.001)。严重的NIHSS入院评分也是90天死亡率和不良功能结局的唯一预测因素(p < 0.05)。结论:在卡塔尔的南亚亚人群中,卒中的表现和结果存在显著差异,这表明,针对不同人群的卒中护理,量身定制的公共卫生策略作为统一方法的重要性是不够的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信