Incidence of syphilitic hepatitis among patients with neurosyphilis.

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Jessica Sun, Louis Wang, Christopher Pokorny
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引用次数: 0

Abstract

Syphilis is a sexually transmitted infection of ongoing public health concern due to its systemic complications, which necessitate early detection and management. As a non-hepatotropic pathogen, syphilis can also cause unexplained hepatitis, a condition that is often overlooked. A retrospective review of 62 patients with neurosyphilis at a metropolitan Australian hospital found that nine (15%) had abnormal liver biochemistry, which improved with antibiotic therapy, consistent with syphilitic hepatitis. This improvement was statistically significant across all liver markers, and the liver pattern of injury was predominantly cholestatic (67%). This study aims to alert clinicians to the incidence and patterns of liver biochemistry abnormalities in syphilis and advise clinicians to perform liver function testing in all patients with neurosyphilis, particularly in high-risk groups. Early detection and diagnosis can prevent unnecessary tests, enable prompt treatment and avoid progression to fulminant hepatitis.

神经梅毒患者中梅毒性肝炎的发病率。
梅毒是一种性传播感染,因其系统性并发症而引起持续的公共卫生关注,需要早期发现和治疗。作为一种非嗜肝性病原体,梅毒也可引起原因不明的肝炎,这是一种经常被忽视的疾病。对澳大利亚一家大城市医院62例神经梅毒患者的回顾性研究发现,9例(15%)患者肝脏生化异常,抗生素治疗后改善,与梅毒肝炎一致。这种改善在所有肝脏指标上都具有统计学意义,肝脏损伤模式主要是胆汁淤积(67%)。本研究旨在提醒临床医生注意梅毒患者肝脏生化异常的发生率和模式,并建议临床医生对所有神经梅毒患者,特别是高危人群进行肝功能检测。早期发现和诊断可以防止不必要的检查,能够及时治疗并避免发展为暴发性肝炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Internal Medicine Journal
Internal Medicine Journal 医学-医学:内科
CiteScore
3.50
自引率
4.80%
发文量
600
审稿时长
3-6 weeks
期刊介绍: The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.
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