Hyperintense lesions suspect for acute cerebral microbleeds on ultra-high field T1 weighted 7 Tesla MRI in patients with cerebral amyloid angiopathy

IF 3.3 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-09-21 DOI:10.1016/j.ejrad.2025.112428

O.F. de Bruin , M.R. Schipper , E.A. Koemans , T.W. van Harten , I. Rasing , K. Kaushik , L. Hirschler , R. van Dort , R.G.J. van der Zwet , M.J.P. van Osch , M.A.A. van Walderveen , M.J.H. Wermer , S. Voigt

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引用次数: 0

Abstract

Objective

The aims of this study are to describe T1 hyperintense lesions on 7 T MRI in patients with hereditary Dutch-type (D-CAA) and sporadic cerebral amyloid angiopathy (sCAA) and their detection rate on 7 T and 3 T MRI.

Methods

We included D-CAA mutation carriers and patients with sCAA who participated between 2018 and 2023 in our natural history studies in D-CAA (AURORA) and sCAA (FOCAS). We assessed T1-weighted 7 T MRI for small (<10 mm) hyperintense lesions and T1-weighted 3 T MRI for corresponding lesions. We classified them as possible acute (1–3 days after onset) CMBs when exhibiting characteristics of CMBs on the T2*-weighted gradient echo sequence (GRE) 7 T and/or susceptibility weighted imaging (SWI) 3 T MRI. Follow-up T1-weighted 7 T and 3 T MRI and T2*-weighted GRE 7 T and/or SWI 3 T MRI were assessed to confirm the hemorrhagic origin of 7 T T1 hyperintense lesions found at baseline.

Results

Baseline 7 T MRI and 3 T MRI was available in 112 participants. We found 16 T1 hyperintense lesions on 7 T in 12 participants (11 %). Of the 16 lesions, 10 (63 %) were subsequently identified on T1-weighted 3 T MRI. In patients with available follow-up imaging, 11 out of 15 lesions (73 %) were classified as acute CMBs based on 7 T and/or 3 T follow-up imaging.

Conclusion

7 T T1 hyperintense lesions were identified in approximately one in ten patients in our cohort. Acute CMBs were more often identified on 7 T MRI in comparison to 3 T MRI. This highlights the additional value of ultra-high field MRI in the assessment of CAA-related MRI markers.

查看原文本刊更多论文

脑淀粉样血管病患者的超高场T1加权7特斯拉MRI显示疑似急性脑微出血的高强度病变。

目的：本研究旨在描述遗传性荷兰型（D-CAA）和散发性脑淀粉样血管病（sCAA）患者在7 T MRI上的T1高信号病变及其在7 T和3 T MRI上的检出率。方法：我们将2018年至2023年间参与D-CAA突变携带者和sCAA患者纳入我们的D-CAA （AURORA）和sCAA （FOCAS）自然史研究。我们评估了t1加权7t MRI对小（结果：基线7t MRI和3t MRI在112名参与者中可用）。我们发现12名参与者（11%）在7个T上有16个T1高信号病变。在16个病变中，10个（63%）随后在t1加权的3t MRI上被发现。在可获得随访影像的患者中，根据7t和/或3t随访影像，15个病变中有11个（73%）被归类为急性CMBs。结论：在我们的队列中，大约十分之一的患者中发现了7个tt1高强度病变。与3t MRI相比，7t MRI更常发现急性CMBs。这突出了超高场MRI在评估caa相关MRI标志物方面的附加价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.