Transcranial direct current stimulation's effect on exercise capacity, respiratory muscle strength, and physical performance in patients with chronic obstructive pulmonary disease: Randomized controlled trial.
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引用次数: 0
Abstract
BackgroundChronic obstructive pulmonary disease (COPD) is associated with alterations in brain function that contribute to reduced respiratory and skeletal muscle strength, ultimately limiting exercise capacity. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has demonstrated efficacy in enhancing lower extremity function in healthy older adults.ObjectiveTo evaluate the effects of a single session of anodal tDCS on exercise capacity, respiratory muscle strength, and physical performance in individuals with COPD.MethodsIn a randomized, double-blind, sham-controlled trial, 26 participants with COPD underwent baseline assessments of exercise capacity (Six-Minute Walk Distance, 6MWD), respiratory muscle strength (Maximum Inspiratory Pressure, MIP), and physical performance (4-m Gait Speed, 4MGS). Participants then received either active or sham tDCS, followed by reassessment 1 day post-intervention.ResultsCompared to sham, the active tDCS group showed significant improvements in physical performance, including increases of 46 ± 11.45 m in 6MWD (p < 0.001), 12.54 ± 4.52 cm, H2O in MIP (p < 0.01), and 0.24 ± 0.08 m/s in 4MGS (p < 0.05).ConclusionA single session of anodal tDCS may enhance exercise capacity, inspiratory muscle strength, and gait speed in patients with COPD, suggesting its potential as a supportive intervention in pulmonary rehabilitation.
背景:慢性阻塞性肺疾病(COPD)与脑功能改变相关,导致呼吸和骨骼肌力量降低,最终限制运动能力。经颅直流电刺激(tDCS)是一种非侵入性神经调节技术,已被证明对改善健康老年人的下肢功能有效。目的评价单次负极tDCS对慢性阻塞性肺病患者运动能力、呼吸肌力量和体能的影响。方法在一项随机、双盲、假对照试验中,26名COPD患者接受了运动能力(6分钟步行距离,6MWD)、呼吸肌力量(最大吸气压力,MIP)和身体表现(4米步态速度,4MGS)的基线评估。然后,参与者接受主动或假性tDCS,干预后1天重新评估。结果与假手术组相比,主动tDCS组的运动能力显著提高,6MWD组提高了46±11.45 m (p < 0.001), MIP组提高了12.54±4.52 cm (p < 0.01), 4MGS组提高了0.24±0.08 m/s (p < 0.05)。结论单次淋巴结tDCS可提高COPD患者的运动能力、吸气肌力量和步态速度,提示其作为肺康复支持干预的潜力。
期刊介绍:
Chronic Respiratory Disease is a peer-reviewed, open access, scholarly journal, created in response to the rising incidence of chronic respiratory diseases worldwide. It publishes high quality research papers and original articles that have immediate relevance to clinical practice and its multi-disciplinary perspective reflects the nature of modern treatment. The journal provides a high quality, multi-disciplinary focus for the publication of original papers, reviews and commentary in the broad area of chronic respiratory disease, particularly its treatment and management.