An updated meta-analysis on the efficacy and safety of medications administered after non-surgical root canal treatment in managing postoperative pain.

Dorsa Samani, Armin Arian, Kimia Kelidari, Mahsa Moosapoor Farkhani, Aida Keshavarzi, Kimia Sadat Kazemi, Sepehr Haghshoar, Sharare Jahangiri, Fereshteh Molaei, Sahar Rajaei, Haleh Fakhimi Rezaei, Sina Ahmadi, Mohaddeseh Belbasi, Alireza Mokhtari Sakhvidi, Mahdyieh Naziri
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Abstract

Effective management is one of the most important factors in mitigating postoperative endodontic pain (PEP). The purpose of this network meta-analysis was to compare the therapeutic effects and safety of different drugs commonly used for pain relief after non-surgical endodontic treatment. We searched the Scopus, PubMed, and Google Scholar databases until February 2024. Titles, abstracts, and full texts were identified according to predetermined criteria. Data were extracted from the selected publications, and a quality assessment was performed for the included studies. Sixteen RCTs with 2,021 participants were included in the meta-analysis. All included studies investigated the impact of NSAIDs on pain reduction in nonsurgical endodontic treatment. A statistically significant reduction in pain was observed at 8 h (pooled effect = -3.10, I2 = 100%), 12 h (pooled effect = -1.69, I2 = 99.2%), 24 h (pooled effect = -1.48, I2 = 99.9%), 48 h (pooled effect = -1.42, I2 = 99.4%), and 72 h (pooled effect = -0.64, I2 = 73.1%) of follow-up. The funnel plot was symmetrical, and sensitivity analysis excluded one article in 72 h follow-up. Overall, this meta-analysis demonstrated that NSAIDs and corticostreoids are statistically effective in relieving pain after non-surgical endodontic treatment. However, owing to the significant differences between studies and heterogenicity, additional randomized controlled trials are needed to validate this correlation further.

一项关于非手术根管治疗后治疗术后疼痛的有效性和安全性的最新荟萃分析。
有效的治疗是缓解术后牙髓疼痛的重要因素之一。本网络荟萃分析的目的是比较非手术根管治疗后常用的不同镇痛药物的疗效和安全性。我们检索了Scopus、PubMed和b谷歌Scholar数据库,直到2024年2月。根据预先确定的标准确定标题、摘要和全文。从选定的出版物中提取数据,并对纳入的研究进行质量评估。meta分析纳入16项随机对照试验,共2021名受试者。所有纳入的研究都调查了非甾体抗炎药在非手术根管治疗中减轻疼痛的影响。在随访8 h(合并效应= -3.10,I2 = 100%)、12 h(合并效应= -1.69,I2 = 99.2%)、24 h(合并效应= -1.48,I2 = 99.9%)、48 h(合并效应= -1.42,I2 = 99.4%)和72 h(合并效应= -0.64,I2 = 73.1%)时,疼痛减轻具有统计学意义。漏斗图对称,敏感性分析排除随访72 h 1篇文章。总的来说,这项荟萃分析表明,非甾体抗炎药和皮质类固醇在缓解非手术牙髓治疗后疼痛方面具有统计学上的有效性。然而,由于研究之间的显著差异和异质性,需要额外的随机对照试验来进一步验证这种相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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