The Role of Endoscopy in Gastroesophageal Reflux Disease.

IF 3.6 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Digestion Pub Date : 2025-09-24 DOI:10.1159/000548088
Hiroko Hosaka, Shiko Kuribayashi, Yuki Itoi, Keigo Sato, Hirohito Tanaka, Yoji Takeuchi, Toshio Uraoka
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引用次数: 0

Abstract

Background: Gastroesophageal reflux disease (GERD) is a common and heterogeneous condition that has traditionally been assessed using endoscopy for visual identification of mucosal injury. In recent years, advances in endoscopic technology have significantly reshaped both the diagnostic and therapeutic approaches to GERD.

Summary: Modern imaging modalities, such as high-resolution and image-enhanced endoscopy, now allow for the detection of subtle mucosal changes. Functional endoscopic techniques, including the Endoscopic Pressure Study Integrated System (EPSIS), enable real-time physiological assessment of esophageal function and contribute to a better understanding of GERD pathophysiology. On the therapeutic front, endoscopy has emerged as a viable, minimally invasive alternative to surgery in managing refractory or proton pump inhibitor (PPI)-dependent GERD. Techniques such as anti-reflux mucosectomy, anti-reflux mucosal ablation (ARMA), and endoscopic submucosal dissection for GERD are increasingly recognized for their safety and efficacy.

Key messages: (a) Modern endoscopic techniques improve the detection of subtle mucosal and functional abnormalities in GERD. (b)Functional endoscopy techniques offer insights into the mechanisms of GERD symptoms and lower esophageal sphincter dysfunction. (c) Endoscopic therapies are minimally invasive treatment options for patients with PPI-refractory or PPI-dependent GERD. (d) Endoscopy is expected to play a central role in the comprehensive management of GERD.

内镜检查在胃食管反流病中的作用。
背景:胃食管反流病(GERD)是一种常见且异质性的疾病,传统上使用内窥镜对粘膜损伤进行视觉识别。近年来,内镜技术的进步极大地改变了胃食管反流的诊断和治疗方法。摘要:现代成像方式,如高分辨率和图像增强内窥镜,现在可以检测细微的粘膜变化。功能内窥镜技术,包括内窥镜压力研究集成系统(EPSIS),能够对食管功能进行实时生理评估,有助于更好地了解胃食管反流病的病理生理。在治疗方面,内窥镜已经成为治疗难治性或质子泵抑制剂(PPI)依赖性胃食管反流的可行的、微创的替代手术。抗反流粘膜切除术、抗反流粘膜消融(ARMA)和内镜下粘膜剥离治疗胃食管反流的技术因其安全性和有效性而越来越得到认可。(a)现代内窥镜技术改善了胃食管反流中细微粘膜和功能异常的检测。(b)功能内窥镜技术提供了对胃反流症状和下食管括约肌功能障碍机制的见解。(c)内镜治疗是ppi难治性或ppi依赖性胃食管反流患者的微创治疗选择。(d)内窥镜检查可望在胃食管反流病的全面治疗中发挥中心作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Digestion
Digestion 医学-胃肠肝病学
CiteScore
7.90
自引率
0.00%
发文量
39
审稿时长
6-12 weeks
期刊介绍: ''Digestion'' concentrates on clinical research reports: in addition to editorials and reviews, the journal features sections on Stomach/Esophagus, Bowel, Neuro-Gastroenterology, Liver/Bile, Pancreas, Metabolism/Nutrition and Gastrointestinal Oncology. Papers cover physiology in humans, metabolic studies and clinical work on the etiology, diagnosis, and therapy of human diseases. It is thus especially cut out for gastroenterologists employed in hospitals and outpatient units. Moreover, the journal''s coverage of studies on the metabolism and effects of therapeutic drugs carries considerable value for clinicians and investigators beyond the immediate field of gastroenterology.
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