{"title":"The Role of Endoscopy in Gastroesophageal Reflux Disease.","authors":"Hiroko Hosaka, Shiko Kuribayashi, Yuki Itoi, Keigo Sato, Hirohito Tanaka, Yoji Takeuchi, Toshio Uraoka","doi":"10.1159/000548088","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gastroesophageal reflux disease (GERD) is a common and heterogeneous condition that has traditionally been assessed using endoscopy for visual identification of mucosal injury. In recent years, advances in endoscopic technology have significantly reshaped both the diagnostic and therapeutic approaches to GERD.</p><p><strong>Summary: </strong>Modern imaging modalities, such as high-resolution and image-enhanced endoscopy, now allow for the detection of subtle mucosal changes. Functional endoscopic techniques, including the Endoscopic Pressure Study Integrated System (EPSIS), enable real-time physiological assessment of esophageal function and contribute to a better understanding of GERD pathophysiology. On the therapeutic front, endoscopy has emerged as a viable, minimally invasive alternative to surgery in managing refractory or proton pump inhibitor (PPI)-dependent GERD. Techniques such as anti-reflux mucosectomy, anti-reflux mucosal ablation (ARMA), and endoscopic submucosal dissection for GERD are increasingly recognized for their safety and efficacy.</p><p><strong>Key messages: </strong>(a) Modern endoscopic techniques improve the detection of subtle mucosal and functional abnormalities in GERD. (b)Functional endoscopy techniques offer insights into the mechanisms of GERD symptoms and lower esophageal sphincter dysfunction. (c) Endoscopic therapies are minimally invasive treatment options for patients with PPI-refractory or PPI-dependent GERD. (d) Endoscopy is expected to play a central role in the comprehensive management of GERD.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"1-9"},"PeriodicalIF":3.6000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestion","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000548088","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Gastroesophageal reflux disease (GERD) is a common and heterogeneous condition that has traditionally been assessed using endoscopy for visual identification of mucosal injury. In recent years, advances in endoscopic technology have significantly reshaped both the diagnostic and therapeutic approaches to GERD.
Summary: Modern imaging modalities, such as high-resolution and image-enhanced endoscopy, now allow for the detection of subtle mucosal changes. Functional endoscopic techniques, including the Endoscopic Pressure Study Integrated System (EPSIS), enable real-time physiological assessment of esophageal function and contribute to a better understanding of GERD pathophysiology. On the therapeutic front, endoscopy has emerged as a viable, minimally invasive alternative to surgery in managing refractory or proton pump inhibitor (PPI)-dependent GERD. Techniques such as anti-reflux mucosectomy, anti-reflux mucosal ablation (ARMA), and endoscopic submucosal dissection for GERD are increasingly recognized for their safety and efficacy.
Key messages: (a) Modern endoscopic techniques improve the detection of subtle mucosal and functional abnormalities in GERD. (b)Functional endoscopy techniques offer insights into the mechanisms of GERD symptoms and lower esophageal sphincter dysfunction. (c) Endoscopic therapies are minimally invasive treatment options for patients with PPI-refractory or PPI-dependent GERD. (d) Endoscopy is expected to play a central role in the comprehensive management of GERD.
期刊介绍:
''Digestion'' concentrates on clinical research reports: in addition to editorials and reviews, the journal features sections on Stomach/Esophagus, Bowel, Neuro-Gastroenterology, Liver/Bile, Pancreas, Metabolism/Nutrition and Gastrointestinal Oncology. Papers cover physiology in humans, metabolic studies and clinical work on the etiology, diagnosis, and therapy of human diseases. It is thus especially cut out for gastroenterologists employed in hospitals and outpatient units. Moreover, the journal''s coverage of studies on the metabolism and effects of therapeutic drugs carries considerable value for clinicians and investigators beyond the immediate field of gastroenterology.