Neurobehavioral assessment of a syndromic Dandy-Walker malformation using 4D ultrasound and KANET: a case report.

IF 0.2 Q4 OBSTETRICS & GYNECOLOGY

Case Reports in Perinatal Medicine Pub Date : 2025-09-23 eCollection Date: 2025-01-01 DOI:10.1515/crpm-2025-0008

Wiku Andonotopo, Muhammad Adrianes Bachnas, Julian Dewantiningrum, Mochammad Besari Adi Pramono, Milan Stanojević, Asim Kurjak

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引用次数: 0

Abstract

Objectives: To evaluate fetal neurobehavior using the Kurjak Antenatal Neurodevelopmental Test (KANET) via 4D ultrasound in a fetus diagnosed with syndromic Dandy-Walker Malformation (DWM), and to correlate these findings with postnatal outcomes.

Case presentation: A 35-year-old woman was referred at 25 weeks' gestation for evaluation of multiple fetal anomalies. Ultrasound revealed hallmark DWM features - cerebellar vermis hypoplasia, enlarged posterior fossa, hydrocephalus - as well as extracranial anomalies including craniofacial dysmorphism, bilateral clubhands and clubfeet, and suspected hypoplastic left heart syndrome. A KANET assessment at 25+3 weeks yielded a severely abnormal score of 3. At 26 weeks, a male infant was delivered and survived 2 h postnatally. All anomalies were confirmed postnatally.

Conclusions: KANET, even when performed slightly earlier than standard timing, provided critical insights into the fetus's neurobehavioral function and correlated strongly with the fatal outcome. This case supports the value of KANET as a non-invasive tool for assessing neurological integrity in complex fetal conditions where third-trimester evaluation may not be possible.

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应用四维超声和KANET评价综合征型Dandy-Walker畸形的神经行为：1例报告。

目的：利用4D超声Kurjak产前神经发育测试（KANET）评估诊断为综合征型ddy - walker畸形（DWM）的胎儿的神经行为，并将这些结果与产后结局联系起来。病例介绍：一名35岁的妇女在妊娠25周时进行了多胎畸形的评估。超声显示标志性的DWM特征-小脑蚓部发育不全，后窝增大，脑积水-以及颅外异常，包括颅面畸形，双侧畸形手和畸形脚，疑似左心发育不良综合征。25+3周时的KANET评分为严重异常3分。在26周时，一名男婴出生并存活了2 h。所有异常均在产后确认。结论：KANET，即使比标准时间稍早，也提供了对胎儿神经行为功能的关键见解，并与致命结果密切相关。该病例支持KANET作为一种非侵入性工具的价值，用于评估复杂胎儿情况下的神经完整性，其中晚期评估可能是不可能的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Perinatal Medicine OBSTETRICS & GYNECOLOGY-

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期刊介绍： Case Reports in Perinatal Medicine is a double-blind peer-reviewed journal. The objective of the new journal is very similar to that of JPM. In addition to evidence-based studies, practitioners in clinical practice esteem especially exemplary reports of cases that reveal specific manifestations of diseases, its progress or its treatment. We consider case reports and series to be brief reports describing an isolated clinical case or a small number of cases. They may describe new or uncommon diagnoses, unusual outcomes or prognosis, new or infrequently used therapies and side effects of therapy not usually discovered in clinical trials. They represent the basic concept of experiences for studies on representative groups for further evidence-based research. The potential roles of case reports and case series are: Recognition and description of new diseases Detection of drug side effects (adverse or beneficial) Study of mechanisms of disease Medical education and audit Recognition of rare manifestations of disease.