Rose Crowley, Sonia Azzopardi, Annie Curtin, Georgia Rendell, Louise Segan, Jeremy William, Kenneth Cho, Nicholas D'Elia, Margareta Sutija, Tommy Kende, David Chieng, Hariharan Sugumar, Aleksandr Voskoboinik, Sandeep Prabhu, Liang-Han Ling, Vaughan G Macefield, Jonathan M Kalman, Peter M Kistler
{"title":"Yoga vs Regular Exercise for Atrial Fibrillation: Design of the Yoga-AF Randomized Controlled Trial.","authors":"Rose Crowley, Sonia Azzopardi, Annie Curtin, Georgia Rendell, Louise Segan, Jeremy William, Kenneth Cho, Nicholas D'Elia, Margareta Sutija, Tommy Kende, David Chieng, Hariharan Sugumar, Aleksandr Voskoboinik, Sandeep Prabhu, Liang-Han Ling, Vaughan G Macefield, Jonathan M Kalman, Peter M Kistler","doi":"10.1016/j.ahj.2025.09.010","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lifestyle modification is a key pillar of AF management. Yoga has beneficial effects on cardiovascular health and has shown promise as an intervention in AF. However, randomised data are absent.</p><p><strong>Objectives: </strong>To determine the effect of regular yoga on AF episodes and AF burden in people with paroxysmal or persistent AF over a 12-month period.</p><p><strong>Methods: </strong>This is a randomised control trial of a yoga program in addition to standard care, compared to standard care alone in people with paroxysmal or persistent AF undergoing a rhythm control management strategy. 222 participants will be randomised 1:1 to the yoga intervention or control. Yoga will be conducted in studio and online with a target of at least 3 classes/week. Controls will be instructed to exercise for at least 150 minutes/week. Rhythm monitoring will be with implantable loop recorder, or ECG capable smartwatch with AF detection and twice daily ECGs. Autonomic metrics will be assessed in the laboratory by HRV, blood pressure variability and direct recordings of muscle sympathetic nerve activity. Following a 3-month training period, the dual primary endpoints of AF recurrence (time to recurrence, as defined by any sustained atrial tachyarrhythmia lasting > 1 hour) and AF burden will be determined at 12 months.</p><p><strong>Conclusions: </strong>This study aims to determine the impact of yoga on AF recurrence and burden in people with paroxysmal and persistent AF. Yoga may provide an effective non-invasive, non-pharmacologic lifestyle strategy in the management of AF.</p><p><strong>Trial registration: </strong>The trial was pre-registered with the Australian New Zealand Clinical Trials Registry (ACTRN12624000264583).</p>","PeriodicalId":7868,"journal":{"name":"American heart journal","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American heart journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ahj.2025.09.010","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Lifestyle modification is a key pillar of AF management. Yoga has beneficial effects on cardiovascular health and has shown promise as an intervention in AF. However, randomised data are absent.
Objectives: To determine the effect of regular yoga on AF episodes and AF burden in people with paroxysmal or persistent AF over a 12-month period.
Methods: This is a randomised control trial of a yoga program in addition to standard care, compared to standard care alone in people with paroxysmal or persistent AF undergoing a rhythm control management strategy. 222 participants will be randomised 1:1 to the yoga intervention or control. Yoga will be conducted in studio and online with a target of at least 3 classes/week. Controls will be instructed to exercise for at least 150 minutes/week. Rhythm monitoring will be with implantable loop recorder, or ECG capable smartwatch with AF detection and twice daily ECGs. Autonomic metrics will be assessed in the laboratory by HRV, blood pressure variability and direct recordings of muscle sympathetic nerve activity. Following a 3-month training period, the dual primary endpoints of AF recurrence (time to recurrence, as defined by any sustained atrial tachyarrhythmia lasting > 1 hour) and AF burden will be determined at 12 months.
Conclusions: This study aims to determine the impact of yoga on AF recurrence and burden in people with paroxysmal and persistent AF. Yoga may provide an effective non-invasive, non-pharmacologic lifestyle strategy in the management of AF.
Trial registration: The trial was pre-registered with the Australian New Zealand Clinical Trials Registry (ACTRN12624000264583).
期刊介绍：
The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.
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