Endoscopic Mastectomy in Patients with Genetic Mutations.

IF 1.8 4区医学 Q3 SURGERY

JSLS : Journal of the Society of Laparoendoscopic Surgeons Pub Date : 2025-07-01 Epub Date: 2025-09-04 DOI:10.4293/JSLS.2025.00070

Guillermo G Peralta-Castillo, Luis Miguel Cornejo-Mota, Luis César Valencia-García, Paulina Bajonero-Canónico, Claudirocy Marely Valladares Yañez

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引用次数: 0

Abstract

Objective: To describe clinical, surgical, and cosmetic outcomes in patients with germline mutations undergoing endoscopic nipple- and skin-sparing mastectomy (eNSM) with immediate reconstruction.

Methods: We conducted a retrospective review of 6 patients (11 breasts) treated between March 2022 and May 2024. All patients had confirmed BRCA1, BRCA2, CHEK2, or MUTYH mutations. Data on operative time, bleeding, specimen weight, reconstruction satisfaction (BRECON 31), complications, and recurrence were collected.

Results: All surgeries were completed without conversion to open surgery. Mean age was 41 ± 9.2 years; mean surgical time was 115.6 ± 11.0 minutes; mean blood loss was 110 ± 70.9 mL. No complications were reported. BRECON 31 satisfaction score at 6 months was 15.3/16. Median follow-up was 13 months with no recurrences.

Conclusions: eNSM is a feasible and effective option for patients with high-risk genetic mutations, offering oncologic safety and high satisfaction in our initial Latin American experience.

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基因突变患者的内镜乳房切除术。

目的：描述生殖系突变患者在内镜下保留乳头和皮肤的乳房切除术（eNSM）并立即重建的临床、手术和美容结果。方法：对2022年3月至2024年5月期间接受治疗的6例患者（11个乳房）进行回顾性分析。所有患者均有BRCA1、BRCA2、CHEK2或MUTYH突变。收集手术时间、出血量、标本重量、重建满意度（BRECON 31）、并发症和复发等数据。结果：所有手术均顺利完成，未转开。平均年龄41±9.2岁；平均手术时间115.6±11.0分钟；平均失血量110±70.9 mL，无并发症报告。BRECON 31 6个月满意度评分为15.3/16。中位随访时间为13个月，无复发。结论：在我们的拉丁美洲初步经验中，enm对于高危基因突变患者是一种可行有效的选择，具有肿瘤安全性和高满意度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JSLS : Journal of the Society of Laparoendoscopic Surgeons SURGERY-

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： JSLS, Journal of the Society of Laparoscopic & Robotic Surgeons publishes original scientific articles on basic science and technical topics in all the fields involved with laparoscopic, robotic, and minimally invasive surgery. CRSLS, MIS Case Reports from SLS is dedicated to the publication of Case Reports in the field of minimally invasive surgery. The journals seek to advance our understandings and practice of minimally invasive, image-guided surgery by providing a forum for all relevant disciplines and by promoting the exchange of information and ideas across specialties.