Anticancer Potential of Antimicrobial Peptides: Focus on Breast Cancer

IF 2.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Wen Yang, Hongyan Hou, Ran Chai, Jiaxiang Guo
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引用次数: 0

Abstract

Breast cancer impacts millions globally, with a significant annual rise in the incidence of new cases. Although considerable progress has been made in cancer therapies and numerous options exist to address this disease, the overall survival rates for individuals with breast cancer remain distinctly low. This situation is attributed to the emergence of resistance against chemotherapeutic agents used for breast cancer, along with the inadequate characteristics of the existing generation of oncological medications. Therefore, there is an imperative necessity for the creation of innovative treatments that exhibit minimal adverse effects, enhanced properties, and the absence of drug resistance. A noteworthy development in this field is the exploration of antimicrobial peptides (AMPs), which are natural constituents of the innate immune system, as a novel class of anticancer therapeutics. AMPs display multiple advantageous traits that make them attractive candidates for cancer therapy. In this review, we will review recent research focused on the application of AMPs in breast cancer therapy and determine their mechanisms of action. We will also investigate the potential of combining AMP-based treatments with existing breast cancer management approaches. This study highlights the promising potential of AMPs as a novel approach to treating breast cancer, providing promise for less harmful and more efficient therapies.

Abstract Image

抗菌肽的抗癌潜力:聚焦于乳腺癌。
乳腺癌影响着全球数百万人,新病例的发病率每年都在显著上升。尽管在癌症治疗方面取得了相当大的进展,并且存在许多治疗这种疾病的选择,但乳腺癌患者的总体存活率仍然非常低。这种情况归因于对用于乳腺癌的化疗药物的耐药性的出现,以及现有一代肿瘤药物的不足特性。因此,迫切需要创造出具有最小副作用、增强性能和无耐药性的创新治疗方法。这一领域一个值得注意的发展是抗菌肽(AMPs)的探索,它是先天免疫系统的天然成分,作为一类新的抗癌治疗药物。amp显示出多种有利特性,使其成为癌症治疗的有吸引力的候选者。本文将对近年来amp在乳腺癌治疗中的应用研究进行综述,并探讨其作用机制。我们还将研究将基于amp的治疗与现有乳腺癌管理方法相结合的潜力。这项研究强调了amp作为一种治疗乳腺癌的新方法的潜力,为更少有害和更有效的治疗提供了希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.80
自引率
2.80%
发文量
277
审稿时长
6-12 weeks
期刊介绍: The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.
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