Dynamic contrast-enhanced ultrasound perfusion analysis for preoperative prediction of aggressive hepatocellular carcinoma subtypes.

IF 4.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-09-23 DOI:10.1186/s13244-025-02052-z

Xin Guan, Xiao Li, Daohui Yang, Chongke Zhao, Dan Lu, Yaqin Zhang, Yikang Sun, Boyang Zhou, Zitong Chen, Xinyuan Hu, Hong Han, Qing Lu, Huixiong Xu, Lifan Wang

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引用次数: 0

Abstract

Objective: To evaluate the potential of dynamic contrast-enhanced ultrasound (CEUS) quantitative parameters in preoperative prediction of macrotrabecular-massive (MTM) subtype and high Ki-67 pattern in hepatocellular carcinoma (HCC) patients.

Materials and methods: This study included a retrospective primary cohort and a multicenter prospective validation cohort comprising HCC patients who underwent surgical resection and preoperative CEUS between January 2023 and April 2024. The Clinic-CEUS model was established by combining clinical data and CEUS features, while the Clinic-Q-CEUS model was constructed by combining clinical data and CEUS features with matched quantitative parameters. Model performance was tested with the area under the receiver operating characteristic curve (AUC) in the validation cohort.

Results: A total of 170 patients (mean age, 61 years ± 11 [SD]; 130 men; primary cohort, n = 118; validation cohort, n = 52) were included. The Clinic-Q-CEUS model better predicted MTM subtype and high Ki-67 pattern than the Clinic-CEUS model (AUC, 0.860 vs. 0.753, p = 0.027 and AUC, 0.836 vs. 0.738, p = 0.036) in the primary cohort, with similar performance in the validation cohort (AUC, 0.868 vs. 0.693, p = 0.046 and AUC, 0.787 vs. 0.610, p = 0.018).

Conclusions: Dynamic CEUS quantification analysis could be used as an effective adjunct tool for preoperative identification of MTM subtype and high Ki-67 pattern in HCC patients.

Critical relevance statement: Dynamic contrast-enhanced ultrasound (CEUS) quantitative parameters can help radiologists more accurately identify aggressive macrotrabecular-massive (MTM) subtype and high Ki-67 pattern in HCC patients preoperatively, which provides useful information for subsequent treatment planning.

Key points: Macrotrabecular-massive (MTM) subtype and high Ki-67 pattern in HCC affect prognosis, but diagnosis relies on invasive histopathology. A clinical-Q-CEUS model performed well in preoperative predicting aggressive HCC subtypes. Quantitative parameters of dynamic CEUS can provide valuable information to help accurately identify aggressive HCC subtypes.

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动态增强超声灌注分析在术前预测侵袭性肝细胞癌亚型中的应用。

目的：探讨动态超声造影（CEUS）定量参数在肝细胞癌（HCC）患者术前预测MTM亚型和高Ki-67型中的应用价值。材料和方法：本研究包括回顾性主要队列和多中心前瞻性验证队列，包括2023年1月至2024年4月期间接受手术切除和术前超声造影的HCC患者。将临床数据与CEUS特征相结合建立临床-CEUS模型，将临床数据与CEUS特征结合匹配定量参数构建临床- q -CEUS模型。在验证队列中，用受试者工作特征曲线下面积（AUC）检验模型的性能。结果：共纳入170例患者，平均年龄61岁±11 [SD]，男性130例，主要队列118例，验证队列52例。在初始队列中，Clinic-Q-CEUS模型比Clinic-CEUS模型更好地预测MTM亚型和高Ki-67模式（AUC, 0.860 vs. 0.753, p = 0.027； AUC, 0.836 vs. 0.738, p = 0.036），在验证队列中也有相似的表现（AUC, 0.868 vs. 0.693, p = 0.046； AUC, 0.787 vs. 0.610, p = 0.018）。结论：动态超声造影定量分析可作为HCC患者MTM亚型和高Ki-67型术前鉴别的有效辅助工具。关键相关性声明：动态对比增强超声（CEUS）定量参数可以帮助放射科医生术前更准确地识别HCC患者的侵袭性大小梁肿块（MTM）亚型和高Ki-67型，为后续治疗计划提供有用信息。重点：MTM亚型和高Ki-67型影响HCC预后，但诊断依赖于浸润性组织病理学。临床- q - ceus模型在术前预测侵袭性HCC亚型方面表现良好。动态超声造影的定量参数可以提供有价值的信息，帮助准确识别侵袭性HCC亚型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.