Early Onset Mycoplasma spp. Infection After Kidney Transplantation: A Systematic Review

IF 1.9 4区医学 Q2 SURGERY

Clinical Transplantation Pub Date : 2025-09-24 DOI:10.1111/ctr.70262

Carlo Galdino Riva, Roberto Cacciola, Giulia Cusumano, Chiara Maria Pia Mansueto, Carlo Alfieri, Federico Ambrogi, Serena Delbue, Andrea Lombardi, Mariano Ferraresso, Evaldo Favi

{"title":"Early Onset Mycoplasma spp. Infection After Kidney Transplantation: A Systematic Review","authors":"Carlo Galdino Riva, Roberto Cacciola, Giulia Cusumano, Chiara Maria Pia Mansueto, Carlo Alfieri, Federico Ambrogi, Serena Delbue, Andrea Lombardi, Mariano Ferraresso, Evaldo Favi","doi":"10.1111/ctr.70262","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>In recent years, there has been a progressive increase in the number of <i>Mycoplasma</i> spp. infections (MIs) reported among kidney transplant (KT) recipients. Although in these patients MIs have been associated with life-threatening complications and graft failure, specific epidemiology, clinical characteristics, diagnostic work-up, and treatment strategies remain undefined.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We performed a systematic review (PubMed, Embase, Scopus, and Cochrane) of MIs after kidney transplantation (PROSPERO ID: CRD42024520942).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Our work summarizes 13 case reports, 7 retrospective case series, and 1 retrospective uncontrolled cohort study, published between 1970 and 2023, collectively reporting 30 episodes of MIs. Due to the scarcity of information, incidence, prevalence, and predisposing factors could not be explored. Time interval between kidney transplantation and MIs ranged between 3 and 120 days. More often, the surgical site (<i>n</i> = 18) or the urinary tract (<i>n</i> = 6) was involved, with most infections sustained by <i>Mycoplasma hominis</i> (<i>n</i> = 28). Clinical features included fever (<i>n</i> = 18), abdominal pain (<i>n</i> = 8), leukocytosis (<i>n</i> = 8), and elevated CRP levels (<i>n</i> = 6). The definitive diagnosis was obtained using microbial cultures (<i>n</i> = 16) or PCR method (<i>n</i> = 12), and the time required for identification varied from 3 to 90 days. Preferred antibiotics were tetracyclines (<i>n</i> = 19) and quinolones (<i>n</i> = 9). Overall, MIs led to 20 surgical interventions, 6 graft losses, and 2 deaths.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Future research projects should consider the epidemiology of <i>Mycoplasma</i> spp. infection in solid organ transplant recipients.</p>\n </section>\n </div>","PeriodicalId":10467,"journal":{"name":"Clinical Transplantation","volume":"39 10","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ctr.70262","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Transplantation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ctr.70262","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

In recent years, there has been a progressive increase in the number of Mycoplasma spp. infections (MIs) reported among kidney transplant (KT) recipients. Although in these patients MIs have been associated with life-threatening complications and graft failure, specific epidemiology, clinical characteristics, diagnostic work-up, and treatment strategies remain undefined.

Methods

We performed a systematic review (PubMed, Embase, Scopus, and Cochrane) of MIs after kidney transplantation (PROSPERO ID: CRD42024520942).

Results

Our work summarizes 13 case reports, 7 retrospective case series, and 1 retrospective uncontrolled cohort study, published between 1970 and 2023, collectively reporting 30 episodes of MIs. Due to the scarcity of information, incidence, prevalence, and predisposing factors could not be explored. Time interval between kidney transplantation and MIs ranged between 3 and 120 days. More often, the surgical site (n = 18) or the urinary tract (n = 6) was involved, with most infections sustained by Mycoplasma hominis (n = 28). Clinical features included fever (n = 18), abdominal pain (n = 8), leukocytosis (n = 8), and elevated CRP levels (n = 6). The definitive diagnosis was obtained using microbial cultures (n = 16) or PCR method (n = 12), and the time required for identification varied from 3 to 90 days. Preferred antibiotics were tetracyclines (n = 19) and quinolones (n = 9). Overall, MIs led to 20 surgical interventions, 6 graft losses, and 2 deaths.

Conclusion

Future research projects should consider the epidemiology of Mycoplasma spp. infection in solid organ transplant recipients.

Abstract Image

查看原文本刊更多论文

肾移植后早期支原体感染：系统综述。

背景：近年来，在肾移植（KT）受者中报告的支原体感染（MIs）的数量逐渐增加。尽管在这些患者中，心肌梗死与危及生命的并发症和移植物衰竭有关，但具体的流行病学、临床特征、诊断检查和治疗策略仍不明确。方法：我们对肾移植后MIs （PROSPERO ID: CRD42024520942）进行了系统评价（PubMed、Embase、Scopus和Cochrane）。结果：我们的工作总结了1970年至2023年间发表的13例病例报告、7个回顾性病例系列和1个回顾性非对照队列研究，共报告了30例MIs发作。由于资料匮乏，无法探究其发病率、患病率及易感因素。肾移植与MIs之间的时间间隔为3 ~ 120天。更常见的是，手术部位（n = 18）或尿路（n = 6）受到影响，大多数感染是由人支原体（n = 28）引起的。临床特征包括发热（n = 18）、腹痛（n = 8）、白细胞增多（n = 8）和CRP水平升高（n = 6）。通过微生物培养（n = 16）或PCR法（n = 12）获得明确诊断，鉴定所需时间从3天到90天不等。首选抗生素为四环素类（n = 19）和喹诺酮类（n = 9）。总体而言，MIs导致20例手术干预，6例移植物丢失，2例死亡。结论：今后的研究工作应考虑实体器官移植受者支原体感染的流行病学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Transplantation 医学-外科

CiteScore

3.70

自引率

4.80%

发文量

286

审稿时长

2 months

期刊介绍： Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored. Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include: Immunology and immunosuppression; Patient preparation; Social, ethical, and psychological issues; Complications, short- and long-term results; Artificial organs; Donation and preservation of organ and tissue; Translational studies; Advances in tissue typing; Updates on transplant pathology;. Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries. Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.