Synthesis of 3,3-dialkyl-substituted isochroman-1,4-diones via copper/photoredox dual-catalyzed carbolactonization of alkenes

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-09-24 DOI:10.1039/d5qo01082a

Pengfei Zhou, Ziyu Jin, Qiuping Ding, Jian-Qiang Chen, Jie Wu

引用次数: 0

Abstract

We report a general and concise method for modular synthesis of various 3,3-dialkyl-substituted isochroman-1,4-diones via copper/photoredox dual-catalyzed carbolactonization of alkenoic acids with NHPI esters. A diverse range of NHPI esters derived from natural products and marketed drugs are successfully compatible with this reaction. With this approach, various alkyl-substituted isochroman-1,4-diones featuring a quaternary carbon center at the α-position of the carbonyl group can be synthesized in good to excellent yields.

查看原文本刊更多论文

铜/光氧化还原双催化烯烃碳内化合成3,3-二烷基取代的异色-1,4-二酮

我们报道了一种通用而简洁的方法，通过铜/光氧化还原双催化烯酸与NHPI酯的碳内酯化，模块化合成各种3,3-二烷基取代的异铬-1,4-二酮。从天然产物和市场上销售的药物中提取的各种NHPI酯都能成功地与该反应相容。用这种方法，可以合成羰基α-位置有季碳中心的各种烷基取代等色罗曼-1,4-二酮，收率很高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.