Lewis Acid-Mediated Intermolecular [2π+2σ] Cycloaddition Between Enol Ethers and Bicyclo[1.1.0]butanes

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-09-23 DOI:10.1039/d5qo01194a

Shijie Zhu, Yukun Meng, Zhifei Zhao, Shi-Wu Li

引用次数: 0

Abstract

A Lewis acid-promoted [2π+2σ] cycloaddition strategy enables the construction of bicyclo[2.1.1]hexanes (BCHs) from enol ethers and bicyclo[1.1.0]butanes (BCBs), with excellent functional group tolerance observed for both reactants. Successful scale-up experiments and further derivatization of BCHs demonstrate the robustness of this methodology for accessing complex carbocyclic frameworks.

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烯醇醚与双环丁烷[1.1.0]分子间[2π+2σ]环加成

Lewis酸促进的[2π+2σ]环加成策略使烯醚和双环[1.1.0]丁烷（BCBs）形成双环[2.1.1]己烷（BCHs），对两种反应物都具有良好的官能团耐受性。成功的放大实验和BCHs的进一步衍生化证明了该方法在获取复杂碳环框架方面的稳健性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.