The value of miR-155 expression in predicting early and long-term outcome of coronary artery bypass grafting surgery.

IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Indian Journal of Thoracic and Cardiovascular Surgery Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI:10.1007/s12055-025-02016-4

Hidayet Demir, Mehmet Altuğ Tunçer, Mehrdad Sheikhvatan

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引用次数: 0

Abstract

Background: The role of the expression of micro ribonucleic acid-155 (miR-155) in the modulation of inflammatory processes leading to the development of arterial atherosclerosis has been studied, but it is still not clear whether the change in the expression of miR-155 can predict the outcomes after the vascularization procedure.

Objective: We assessed the value of assessing preoperative miR-155 expression for determining the severity of coronary artery involvement and then determined the association of the expression of this micro ribonucleic acid (microRNA) and poorer outcome of coronary artery bypass surgery.

Methods: The background information was collected by reviewing the hospital database. To assess the level of miR-155, quantitative reverse transcriptase-polymerase chain reaction was set up using the Taq Polymerase plus PacMan (TaqMan) Assay kit. To evaluate the outcomes after surgery, patients were asked by telephone calls.

Results: The mean miR-155 expression value in the patients with one, two, and three involved coronaries was 1.57 ± 0.21, 1.27 ± 0.28, and 1.23 ± 0.29 respectively indicating a lower level of expression in those with three-vessel disease as compared to other disease subgroups. The Gensini score was adversely associated with the level of miR-155 expression. The miR-155 expression level in patients who died in the hospital was significantly lower than in surviving patients. The presence of long-term major cardiovascular adverse events was associated with a lower level of miR-155 expression. These findings were also obtained after adjusting for background factors.

Conclusion: Decreased expression of the miR-155 is associated with increased risk of mortality and long-term complications after coronary artery bypass surgery.

Graphical abstract:

Supplementary information: The online version contains supplementary material available at 10.1007/s12055-025-02016-4.

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miR-155表达在预测冠状动脉搭桥术早期和远期预后中的价值。

背景：已经研究了微核糖核酸-155 （miR-155）表达在炎症过程中导致动脉粥样硬化发展的调节作用，但miR-155表达的变化是否可以预测血管化手术后的结果尚不清楚。目的：我们评估术前评估miR-155表达对确定冠状动脉受损伤严重程度的价值，然后确定这种微核糖核酸（microRNA）的表达与冠状动脉搭桥手术预后较差的关系。方法：通过查阅医院数据库收集背景资料。为了评估miR-155的水平，使用Taq Polymerase + PacMan (TaqMan) Assay kit建立定量逆转录-聚合酶链反应。为了评估手术后的结果，通过电话询问患者。结果：1、2、3支冠脉受累患者miR-155的平均表达值分别为1.57±0.21、1.27±0.28和1.23±0.29，表明三支冠脉病变患者miR-155的表达水平低于其他疾病亚组。Gensini评分与miR-155表达水平呈负相关。院内死亡患者的miR-155表达水平明显低于存活患者。长期主要心血管不良事件的存在与较低水平的miR-155表达相关。这些发现也是在调整背景因素后得出的。结论：miR-155表达降低与冠状动脉搭桥术后死亡率和远期并发症风险增加相关。图片摘要：补充信息：在线版本包含补充资料，提供地址为10.1007/s12055-025-02016-4。

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来源期刊

Indian Journal of Thoracic and Cardiovascular Surgery CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.20

自引率

14.30%

发文量

141

期刊介绍： The primary aim of the Indian Journal of Thoracic and Cardiovascular Surgery is education. The journal aims to dissipate current clinical practices and developments in the area of cardiovascular and thoracic surgery. This includes information on cardiovascular epidemiology, aetiopathogenesis, clinical manifestation etc. The journal accepts manuscripts from cardiovascular anaesthesia, cardiothoracic and vascular nursing and technology development and new/innovative products.The journal is the official publication of the Indian Association of Cardiovascular and Thoracic Surgeons which has a membership of over 1000 at present.DescriptionThe journal is the official organ of the Indian Association of Cardiovascular-Thoracic Surgeons. It was started in 1982 by Dr. Solomon Victor and ws being published twice a year up to 1996. From 2000 the editorial office moved to Delhi. From 2001 the journal was extended to quarterly and subsequently four issues annually have been printed out at time and regularly without fail. The journal receives manuscripts from members and non-members and cardiovascular surgeons. The manuscripts are peer reviewed by at least two or sometimes three or four reviewers who are on the panel. The manuscript process is now completely online. Funding the journal comes partially from the organization and from revenue generated by subscription and advertisement.