The parallel and combinatorial synthesis and screening in drug discovery

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Árpád Furka
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引用次数: 0

Abstract

Nowadays, the pipelines of drug candidates leading to new small-molecule drugs are fed by leads selected from large compound libraries produced by parallel and combinatorial synthetic methods. Tibetan monks long ago discovered how to improve the effectiveness of their prayers by operating prayer wheels in parallel. In traditional chemistry, however, new compounds were synthesized and screened individually. A new era began in the second half of the last century. Following a few attempts, two new methods spread which significantly increased the efficiency of chemical synthesis and screening of compounds: the parallel and combinatorial methods.

药物发现中的平行组合合成与筛选
如今,从平行合成和组合合成方法产生的大型化合物文库中选择的先导物为候选药物的管道提供了新的小分子药物。然而,在传统化学中,新化合物是单独合成和筛选的。上个世纪下半叶开始了一个新的时代。经过几次尝试,两种新的方法得到了广泛的应用,它们大大提高了化学合成和化合物筛选的效率:平行法和组合法。
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来源期刊
Structural Chemistry
Structural Chemistry 化学-化学综合
CiteScore
3.80
自引率
11.80%
发文量
227
审稿时长
3.7 months
期刊介绍: Structural Chemistry is an international forum for the publication of peer-reviewed original research papers that cover the condensed and gaseous states of matter and involve numerous techniques for the determination of structure and energetics, their results, and the conclusions derived from these studies. The journal overcomes the unnatural separation in the current literature among the areas of structure determination, energetics, and applications, as well as builds a bridge to other chemical disciplines. Ist comprehensive coverage encompasses broad discussion of results, observation of relationships among various properties, and the description and application of structure and energy information in all domains of chemistry. We welcome the broadest range of accounts of research in structural chemistry involving the discussion of methodologies and structures,experimental, theoretical, and computational, and their combinations. We encourage discussions of structural information collected for their chemicaland biological significance.
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